El grado de obesidad modifica la respuesta de disminución de circunferencia de cintura en pacientes que reciben 15 mg diarios de sibutramina. Estudio abierto sobre tolerancia y efectividad de la sibutramina

Translated title of the contribution: Obesity type modifies response of decreased waist circumference in patients receiving 15 mg of sibutramine daily. Open study on tolerance and effectiveness of sibutramine

Juan Carlos López-Alvarenga, José Antonio Vargas, Oliver Paul Schneider-Ehrenberg, Anthony G. Comuzzie, Jorge González, José Luis Martínez

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: The etiology, comorbidity, metabolism, and treatment response vary among overweight and obesity types I, II and III individuals. We assessed the association between obesity type with body mass index, waist circumference and tolerance to a daily dose of 15 mg of sibutramine. Materials and methods: A sample of 701 individuals recruited from 47 health centers was analyzed. All subjects received 15 mg of sibutramine daily for 8 weeks. Weight, height, and waist circumference were measured at day 0 and weeks 4 and 8. Results: Patients in all obesity types lost proportional amounts of weight (p=0.86), but those in type III obesity had a smaller reduction in waist circumference than those in types I and II (p=0.003). Side effects of sibutramine were rarely observed. Subjects with type III obesity exhibited even fewer side effects. Conclusions: The lack of association between weight reduction and decreased waist circumference across obesity types could be related to differences in the sympathetic nervous system or to sibutramine biodistribution. Subjects with body mass index greater than 40 Kg/m2 required a higher dose of sibutramine in order to loose the same proportion of abdominal fat as those in other types of obesity.

    Translated title of the contributionObesity type modifies response of decreased waist circumference in patients receiving 15 mg of sibutramine daily. Open study on tolerance and effectiveness of sibutramine
    Original languageSpanish
    Pages (from-to)109-114
    Number of pages6
    JournalGaceta Medica de Mexico
    Volume143
    Issue number2
    StatePublished - 2007

    Keywords

    • Abdominal obesity
    • Obesity
    • Sibutramine
    • Sympathetic system

    ASJC Scopus subject areas

    • Medicine(all)

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