Obesity Related Kidney Disease

Anna V. Mathew, Shinichi Okada, Kumar Sharma

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Obesity is a risk factor for both de novo disease and as a complication of existing chronic kidney disease. Obesity related disease is characterized by albuminuria, glomerulomegaly and secondary focal glomerulosclerosis. Traditionally altered renal hemodynamics causing hyperfiltration and upregulated renin angiotensin system have been associated with these changes. Recently identified circulating factors produced by fat stores such as adiponectin, leptin and inflammatory markers have shown to directly affect the cells in the renal glomeruli and cause pathological changes. Weight loss, blockade of the renin angiotensin system and restoration of adipokine levels may be beneficial to ameliorate the progression of obesity related disease.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalCurrent diabetes reviews
Volume7
Issue number1
StatePublished - Mar 23 2011
Externally publishedYes

Keywords

  • Adiponectin
  • Albuminuria
  • Focal sclerosis
  • Kidney disease
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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