Abstract
The ability of insulin to promote extrarenal potassium uptake and to stimulate glucose uptake was examined in eight obese and ten normal weight control subjects. Insulin was infused at three rates to produced plasma insulin concentrations of approximately 100, 1,900, and 19,000 μU/mL. Insulin-mediated potassium, as well as glucose uptake, was diminished during the lowest dose insulin clamp study (100 μU/mL) but could be normalized at pharmacologic plasma insulin concentrations. These results indicate that obese subjects are resistant to the ability of insulin to stimulate potassium uptake by extrarenal tissues. Imparied potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-108 |
| Number of pages | 4 |
| Journal | Metabolism |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Obesity is associated with impaired insulin-mediated potassium uptake. / Defronzo, Ralph A.
In: Metabolism, Vol. 37, No. 2, 1988, p. 105-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity is associated with impaired insulin-mediated potassium uptake
AU - Defronzo, Ralph A
PY - 1988
Y1 - 1988
N2 - The ability of insulin to promote extrarenal potassium uptake and to stimulate glucose uptake was examined in eight obese and ten normal weight control subjects. Insulin was infused at three rates to produced plasma insulin concentrations of approximately 100, 1,900, and 19,000 μU/mL. Insulin-mediated potassium, as well as glucose uptake, was diminished during the lowest dose insulin clamp study (100 μU/mL) but could be normalized at pharmacologic plasma insulin concentrations. These results indicate that obese subjects are resistant to the ability of insulin to stimulate potassium uptake by extrarenal tissues. Imparied potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues.
AB - The ability of insulin to promote extrarenal potassium uptake and to stimulate glucose uptake was examined in eight obese and ten normal weight control subjects. Insulin was infused at three rates to produced plasma insulin concentrations of approximately 100, 1,900, and 19,000 μU/mL. Insulin-mediated potassium, as well as glucose uptake, was diminished during the lowest dose insulin clamp study (100 μU/mL) but could be normalized at pharmacologic plasma insulin concentrations. These results indicate that obese subjects are resistant to the ability of insulin to stimulate potassium uptake by extrarenal tissues. Imparied potassium uptake at physiologic plasma insulin levels, with normalization at supraphysiologic insulin concentrations, is most consistent with a decrease in the number of insulin receptors on insulin target tissues.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023835576&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(98)90001-4
DO - 10.1016/S0026-0495(98)90001-4
M3 - Article
C2 - 3277011
AN - SCOPUS:0023835576
VL - 37
SP - 105
EP - 108
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 2
ER -