Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

Yiqiang Zhang, Kathleen E. Fischer, Vanessa Soto, Yuhong Liu, Danuta Sosnowska, Arlan Richardson, Adam Salmon

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelerated aging. Obesity is associated with significant increases in oxidative stress in vivo and, despite the well-explored relationship between oxidative stress and aging, the role this plays in the increased mortality of obese subjects remains an unanswered question. Here, we addressed this by undertaking a comprehensive, longitudinal study of a group of high fat-fed obese mice and assessed both their changes in oxidative stress and in their performance in physiological assays known to decline with aging. In female C57BL/6J mice fed a high-fat diet starting in adulthood, mortality was significantly increased as was oxidative damage in vivo. High fat-feeding significantly accelerated the decline in performance in several assays, including activity, gait, and rotarod. However, we also found that obesity had little effect on other markers of function and actually improved performance in grip strength, a marker of muscular function. Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process.

Original languageEnglish (US)
JournalArchives of Biochemistry and Biophysics
DOIs
StateAccepted/In press - Sep 10 2014

Fingerprint

Oxidative stress
Oxidative Stress
Obesity
Aging of materials
Fats
Mortality
Assays
Obese Mice
High Fat Diet
Hand Strength
Nutrition
Gait
Inbred C57BL Mouse
Longitudinal Studies
Chronic Disease
Cardiovascular Diseases
Morbidity
Neoplasms

Keywords

  • Gait
  • Grip strength
  • Longevity
  • Obesity
  • Oxidation
  • Respirometry
  • Rotarod

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. / Zhang, Yiqiang; Fischer, Kathleen E.; Soto, Vanessa; Liu, Yuhong; Sosnowska, Danuta; Richardson, Arlan; Salmon, Adam.

In: Archives of Biochemistry and Biophysics, 10.09.2014.

Research output: Contribution to journalArticle

Zhang, Yiqiang ; Fischer, Kathleen E. ; Soto, Vanessa ; Liu, Yuhong ; Sosnowska, Danuta ; Richardson, Arlan ; Salmon, Adam. / Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. In: Archives of Biochemistry and Biophysics. 2014.
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