Abstract
Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelerated aging. Obesity is associated with significant increases in oxidative stress in vivo and, despite the well-explored relationship between oxidative stress and aging, the role this plays in the increased mortality of obese subjects remains an unanswered question. Here, we addressed this by undertaking a comprehensive, longitudinal study of a group of high fat-fed obese mice and assessed both their changes in oxidative stress and in their performance in physiological assays known to decline with aging. In female C57BL/6J mice fed a high-fat diet starting in adulthood, mortality was significantly increased as was oxidative damage in vivo. High fat-feeding significantly accelerated the decline in performance in several assays, including activity, gait, and rotarod. However, we also found that obesity had little effect on other markers of function and actually improved performance in grip strength, a marker of muscular function. Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process.
| Original language | English (US) |
|---|---|
| Journal | Archives of Biochemistry and Biophysics |
| DOIs | |
| State | Accepted/In press - Sep 10 2014 |
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Keywords
- Gait
- Grip strength
- Longevity
- Obesity
- Oxidation
- Respirometry
- Rotarod
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. / Zhang, Yiqiang; Fischer, Kathleen E.; Soto, Vanessa; Liu, Yuhong; Sosnowska, Danuta; Richardson, Arlan; Salmon, Adam.
In: Archives of Biochemistry and Biophysics, 10.09.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice
AU - Zhang, Yiqiang
AU - Fischer, Kathleen E.
AU - Soto, Vanessa
AU - Liu, Yuhong
AU - Sosnowska, Danuta
AU - Richardson, Arlan
AU - Salmon, Adam
PY - 2014/9/10
Y1 - 2014/9/10
N2 - Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelerated aging. Obesity is associated with significant increases in oxidative stress in vivo and, despite the well-explored relationship between oxidative stress and aging, the role this plays in the increased mortality of obese subjects remains an unanswered question. Here, we addressed this by undertaking a comprehensive, longitudinal study of a group of high fat-fed obese mice and assessed both their changes in oxidative stress and in their performance in physiological assays known to decline with aging. In female C57BL/6J mice fed a high-fat diet starting in adulthood, mortality was significantly increased as was oxidative damage in vivo. High fat-feeding significantly accelerated the decline in performance in several assays, including activity, gait, and rotarod. However, we also found that obesity had little effect on other markers of function and actually improved performance in grip strength, a marker of muscular function. Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process.
AB - Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelerated aging. Obesity is associated with significant increases in oxidative stress in vivo and, despite the well-explored relationship between oxidative stress and aging, the role this plays in the increased mortality of obese subjects remains an unanswered question. Here, we addressed this by undertaking a comprehensive, longitudinal study of a group of high fat-fed obese mice and assessed both their changes in oxidative stress and in their performance in physiological assays known to decline with aging. In female C57BL/6J mice fed a high-fat diet starting in adulthood, mortality was significantly increased as was oxidative damage in vivo. High fat-feeding significantly accelerated the decline in performance in several assays, including activity, gait, and rotarod. However, we also found that obesity had little effect on other markers of function and actually improved performance in grip strength, a marker of muscular function. Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process.
KW - Gait
KW - Grip strength
KW - Longevity
KW - Obesity
KW - Oxidation
KW - Respirometry
KW - Rotarod
UR - http://www.scopus.com/inward/record.url?scp=84920915322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920915322&partnerID=8YFLogxK
U2 - 10.1016/j.abb.2014.12.018
DO - 10.1016/j.abb.2014.12.018
M3 - Article
C2 - 25558793
AN - SCOPUS:84930542885
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
ER -