Obesity, body fat distribution and sex hormones in men

S. M. Haffner, R. A. Valdez, M. P. Stern, M. S. Katz

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

An unfavourable body fat distribution may cause metabolic abnormalities including diabetes and dyslipidemia. These effects may be mediated by alterations in sex hormones. In women the available data suggest that upper body adiposity is related to increased androgenicity (especially as indicated by low concentrations of sex hormone binding globulin). Few data, however, are available on these relationships in men. We therefore examined the association of total testosterone, free testosterone, oestradiol, dehydroepiandrosterone sulphate (DHEA-SO4) and sex hormone binding globulin (SHBG) to waist-to-hip ratio (WHR) and conicity index in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. The conicity index is equal to the abdominal circumference divided by 0.109 x the square root of (weight/height). The conicity index and WHR were significantly inversely related to DHEA-SO4 and free testosterone. SHBG was only weakly associated with body mass index (r = -0.18, P < 0.05). After adjustment for age and body mass index, DHEA-SO4 remained inversely correlated with WHR (r = -0.22, P < 0.01) and conicity index (r = -0.31, P < 0.001) and free testosterone remained inversely associated with conicity index (r = -0.21, P 0.01). Thus, in men, the association between unfavourable body fat distribution and increased androgenicity is inverse in contrast to the situation in women.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalInternational Journal of Obesity
Volume17
Issue number11
StatePublished - 1993

Fingerprint

Body Fat Distribution
prasterone
body fat distribution
sex hormones
Gonadal Steroid Hormones
waist-to-hip ratio
Sex Hormone-Binding Globulin
testosterone
Waist-Hip Ratio
Dehydroepiandrosterone
Testosterone
obesity
Obesity
body mass index
diabetes
Body Mass Index
Dehydroepiandrosterone Sulfate
Adiposity
adiposity
hyperlipidemia

Keywords

  • Age
  • Body fat distribution
  • DHEA-SO
  • Obesity
  • Oestradiol
  • Sex hormone binding globulin
  • Sex Hormones
  • Testosterone

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Haffner, S. M., Valdez, R. A., Stern, M. P., & Katz, M. S. (1993). Obesity, body fat distribution and sex hormones in men. International Journal of Obesity, 17(11), 643-649.

Obesity, body fat distribution and sex hormones in men. / Haffner, S. M.; Valdez, R. A.; Stern, M. P.; Katz, M. S.

In: International Journal of Obesity, Vol. 17, No. 11, 1993, p. 643-649.

Research output: Contribution to journalArticle

Haffner, SM, Valdez, RA, Stern, MP & Katz, MS 1993, 'Obesity, body fat distribution and sex hormones in men', International Journal of Obesity, vol. 17, no. 11, pp. 643-649.
Haffner SM, Valdez RA, Stern MP, Katz MS. Obesity, body fat distribution and sex hormones in men. International Journal of Obesity. 1993;17(11):643-649.
Haffner, S. M. ; Valdez, R. A. ; Stern, M. P. ; Katz, M. S. / Obesity, body fat distribution and sex hormones in men. In: International Journal of Obesity. 1993 ; Vol. 17, No. 11. pp. 643-649.
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