Abstract
Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 564-577 |
| Number of pages | 14 |
| Journal | Annals of Medicine |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- Brown adipose tissue
- Circadian rhythms
- Light:dark cycle
- Melatonin
- Metabolic syndrome
- Obesity
- Sleep
ASJC Scopus subject areas
- Medicine(all)
Cite this
Obesity and metabolic syndrome : Association with chronodisruption, sleep deprivation, and melatonin suppression. / Reiter, Russel J; Tan, Dun Xian; Korkmaz, Ahmet; Ma, Shuran.
In: Annals of Medicine, Vol. 44, No. 6, 09.2012, p. 564-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity and metabolic syndrome
T2 - Association with chronodisruption, sleep deprivation, and melatonin suppression
AU - Reiter, Russel J
AU - Tan, Dun Xian
AU - Korkmaz, Ahmet
AU - Ma, Shuran
PY - 2012/9
Y1 - 2012/9
N2 - Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.
AB - Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.
KW - Brown adipose tissue
KW - Circadian rhythms
KW - Light:dark cycle
KW - Melatonin
KW - Metabolic syndrome
KW - Obesity
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84865627272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865627272&partnerID=8YFLogxK
U2 - 10.3109/07853890.2011.586365
DO - 10.3109/07853890.2011.586365
M3 - Article
C2 - 21668294
AN - SCOPUS:84865627272
VL - 44
SP - 564
EP - 577
JO - Annals of Medicine
JF - Annals of Medicine
SN - 0785-3890
IS - 6
ER -