Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression

Russel J Reiter, Dun Xian Tan, Ahmet Korkmaz, Shuran Ma

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.

Original languageEnglish (US)
Pages (from-to)564-577
Number of pages14
JournalAnnals of Medicine
Volume44
Issue number6
DOIs
StatePublished - Sep 2012

Fingerprint

Sleep Deprivation
Melatonin
Obesity
Life Style
Sleep
Absenteeism
Body Weight Changes
Developed Countries
Developing Countries
Weight Gain
Industry
Economics
Morbidity
Delivery of Health Care
Efficiency
Light
Costs and Cost Analysis
Food

Keywords

  • Brown adipose tissue
  • Circadian rhythms
  • Light:dark cycle
  • Melatonin
  • Metabolic syndrome
  • Obesity
  • Sleep

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Obesity and metabolic syndrome : Association with chronodisruption, sleep deprivation, and melatonin suppression. / Reiter, Russel J; Tan, Dun Xian; Korkmaz, Ahmet; Ma, Shuran.

In: Annals of Medicine, Vol. 44, No. 6, 09.2012, p. 564-577.

Research output: Contribution to journalArticle

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