Abstract
Purpose of review To provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity. Recent findings It is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state. Summary Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-b may contribute to reducing adipose inflammation that may also provide renoprotection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-36 |
| Number of pages | 9 |
| Journal | Current Opinion in Nephrology and Hypertension |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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Keywords
- AMPK
- HIF-1α
- NADPH oxidase
- Nutrient stress
- TGF-β
ASJC Scopus subject areas
- Internal Medicine
- Nephrology
Cite this
Obesity and kidney disease : Differential effects of obesity on adipose tissue and kidney inflammation and fibrosis. / Declèves, Anne Emilie; Sharma, Kumar.
In: Current Opinion in Nephrology and Hypertension, Vol. 24, No. 1, 01.01.2015, p. 28-36.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Obesity and kidney disease
T2 - Differential effects of obesity on adipose tissue and kidney inflammation and fibrosis
AU - Declèves, Anne Emilie
AU - Sharma, Kumar
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose of review To provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity. Recent findings It is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state. Summary Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-b may contribute to reducing adipose inflammation that may also provide renoprotection.
AB - Purpose of review To provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity. Recent findings It is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state. Summary Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-b may contribute to reducing adipose inflammation that may also provide renoprotection.
KW - AMPK
KW - HIF-1α
KW - NADPH oxidase
KW - Nutrient stress
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=84918503918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918503918&partnerID=8YFLogxK
U2 - 10.1097/MNH.0000000000000087
DO - 10.1097/MNH.0000000000000087
M3 - Review article
VL - 24
SP - 28
EP - 36
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
SN - 1062-4821
IS - 1
ER -