Nyctohemeral rhythmicity of type II thyroxine 5′-deiodinase activity in the pineal gland but not in the Harderian gland of the Swiss mouse

A. Rubio, C. Osuna, M. A. Lopez-Gonzalez, R. J. Reiter, J. M. Guerrero

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Type II thyroxine 5′-deiodinase (5′-D) activity in both pineal and Harderian glands of the Swiss mouse was studied. Pineal 5′-D activity exhibited a nyctohemeral profile with a maximal peak value at 05.00 h, which coincides with that for pineal melatonin production. However, no rhythm of 5′-D activity in the Harderian gland could be found. In pineal gland, light at night inhibited the nocturnal increase in 5′-D activity, while isoproterenol, a β-adrenergic agonist, could not stimulate the enzyme. In the Harderian gland, neither darkness, nor light at night, or isoproterenol were capable of modifying basal values of 5′-D activity.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalBioscience Reports
Volume11
Issue number2
DOIs
StatePublished - Apr 1 1991

Keywords

  • Harderian
  • Swiss mouse
  • deiodinase
  • pineal
  • thyroxine

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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