Nyctohemeral profile of type II thyroxine 5'-deiodinase activity in the pineal and Harderian glands of the swiss mouse

C. Osuna, A. Rubio, J. Jimenez, R. J. Reiter, J. M. Guerrero

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Abstract

Type II thyroxine 5'-deiodinase activity in both pineal and Harderian glands of the swiss mouse were studied. We show that pineal 5'-deiodinase activity exhibits a nyctohemeral profile with a maximal peak value at 05.00 h coincident with that for pineal melatonin. However, no rhythm of 5'-deiodinase activity was found in the Harderian gland. These results suggest at least a common regulatory mechanism for type II thyroxine 5'-deiodinase and melatonin production, and probably, an interrelationship between these two metabolic pathways.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalAnnual Review of Chronopharmacology
Volume7
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Pharmacology

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