Abstract
Type II thyroxine 5'-deiodinase activity in both pineal and Harderian glands of the swiss mouse were studied. We show that pineal 5'-deiodinase activity exhibits a nyctohemeral profile with a maximal peak value at 05.00 h coincident with that for pineal melatonin. However, no rhythm of 5'-deiodinase activity was found in the Harderian gland. These results suggest at least a common regulatory mechanism for type II thyroxine 5'-deiodinase and melatonin production, and probably, an interrelationship between these two metabolic pathways.
Original language | English (US) |
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Pages (from-to) | 21-24 |
Number of pages | 4 |
Journal | Annual Review of Chronopharmacology |
Volume | 7 |
State | Published - 1990 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology