Abstract
Type II thyroxine 5'-deiodinase activity in both pineal and Harderian glands of the swiss mouse were studied. We show that pineal 5'-deiodinase activity exhibits a nyctohemeral profile with a maximal peak value at 05.00 h coincident with that for pineal melatonin. However, no rhythm of 5'-deiodinase activity was found in the Harderian gland. These results suggest at least a common regulatory mechanism for type II thyroxine 5'-deiodinase and melatonin production, and probably, an interrelationship between these two metabolic pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Annual Review of Chronopharmacology |
| Volume | 7 |
| State | Published - Jan 1 1990 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Osuna, C., Rubio, A., Jimenez, J., Reiter, R. J., & Guerrero, J. M. (1990). Nyctohemeral profile of type II thyroxine 5'-deiodinase activity in the pineal and Harderian glands of the swiss mouse. Annual Review of Chronopharmacology, 7, 21-24.