Nutritional vitamin b12 deficiency in infancy: Three case reports and a review of the literature

J. J. Doyle, A. M. Langevin, A. Zipursky

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Three cases of vitamin B12 deficiency that occurred during infancy are presented. These cases appeared to be the result of pre-existing maternal deficiency. All three infants demonstrated evidence of neurodevelopmental delay at presentation, and one had sustained loss of milestones and developed involuntary motor movements. Prior to the initiation of therapy, all three infants were anemic: one was thrombocytopenic and one pancytopenic. In all three cases the hematologic and neurologic abnormalities were corrected with vitamin B12 therapy. The literature is reviewed and discussed with respect to the mechanism of the infants' vitamin B12 deficiency and neurodevelopmental manifestations.

Original languageEnglish (US)
Pages (from-to)161-172
Number of pages12
JournalPediatric Hematology and Oncology
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Keywords

  • Developmental delay
  • Megaloblastic anemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Nutritional vitamin b<sub>12</sub> deficiency in infancy: Three case reports and a review of the literature'. Together they form a unique fingerprint.

  • Cite this