TY - JOUR
T1 - Nutritional influences on aging of Fischer 344 rats
T2 - I. Physical, metabolic, and longevity characteristics
AU - Byung Pal Yu, Pal Yu
AU - Masoro, E. J.
AU - McMahan, C. A.
PY - 1985
Y1 - 1985
N2 - The aims of this research were (a) to compare food restriction initiated in adult life of male Fischer 344 rats with that limited to early life or involving most of the life span on physical, metabolic, and longevity characteristics and (b) to study a similar level of protein restriction without caloric restriction on these characteristics. Food restriction (60% of the ad libitum intake) initiated at 6 months of age markedly increased life span as did a similar restriction started at 6 weeks of age, but food restriction limited to early life (6 weeks to 6 months of age) and protein restriction caused only a small increase in longevity. Food restriction does not act by reducing the intake of calories or other nutrient per gram of body mass, a finding not in accord with classic views. A progressive decrease in spontaneous locomotive activity with age occurred in ad libitum fed but not restricted rats.
AB - The aims of this research were (a) to compare food restriction initiated in adult life of male Fischer 344 rats with that limited to early life or involving most of the life span on physical, metabolic, and longevity characteristics and (b) to study a similar level of protein restriction without caloric restriction on these characteristics. Food restriction (60% of the ad libitum intake) initiated at 6 months of age markedly increased life span as did a similar restriction started at 6 weeks of age, but food restriction limited to early life (6 weeks to 6 months of age) and protein restriction caused only a small increase in longevity. Food restriction does not act by reducing the intake of calories or other nutrient per gram of body mass, a finding not in accord with classic views. A progressive decrease in spontaneous locomotive activity with age occurred in ad libitum fed but not restricted rats.
UR - http://www.scopus.com/inward/record.url?scp=0022381249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022381249&partnerID=8YFLogxK
U2 - 10.1093/geronj/40.6.657
DO - 10.1093/geronj/40.6.657
M3 - Article
C2 - 4056321
AN - SCOPUS:0022381249
VL - 40
SP - 657
EP - 670
JO - Journal of Gerontology: Social Sciences
JF - Journal of Gerontology: Social Sciences
SN - 0022-1422
IS - 6
ER -