Nutrition-based interventions for mood disorders

Lais B. Martins, Jenneffer Rayane Braga Tibães, Marsal Sanches, Felice Jacka, Michael Berk, Antônio L. Teixeira

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Introduction: ‘Nutritional Psychiatry’ is an emerging area of research that has great potential as an adjunctive tool for the prevention and treatment of diverse neuropsychiatric disorders. Several nutrition-related aspects, such as obesity, dietary patterns, gut microbiome composition and gut permeability, bioactive food compounds, and nutrients can influence pathways implicated in the pathophysiology of mood disorders. Areas covered: Here, the authors review the current evidence on nutrition–mood interaction and nutrition-based treatments for the two main mood disorders, i.e., major depressive disorder and bipolar disorder. Expert opinion: Consistent evidence from observational studies has pointed out the association between a ‘healthy’ diet, generally characterized by a higher intake of fruits, vegetables, legumes, nuts, whole grains, and good quality sources of protein (i.e. fish and/or seafood), and decreased risk of mood disorders and the parallel association between a ‘Western’ diet pattern and increased risk. However, only a few clinical trials have evaluated the effect of nutritional interventions on the treatment of these conditions. The bidirectional interaction between the brain and the gut, named ‘brain-gut-microbiome axis’ or ‘gut-brain axis’, plays a key role in the link between nutrition and mood disorders. Therefore, nutrition-based strategies for gut microbiota modulation are promising fields in mood disorders.

Original languageEnglish (US)
Pages (from-to)303-315
Number of pages13
JournalExpert Review of Neurotherapeutics
Issue number3
StatePublished - 2021
Externally publishedYes


  • bipolar disorder
  • depressive disorder
  • diet
  • microbiota
  • mood disorders
  • nutrients
  • Nutrition
  • probiotics

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Pharmacology (medical)


Dive into the research topics of 'Nutrition-based interventions for mood disorders'. Together they form a unique fingerprint.

Cite this