TY - JOUR
T1 - Nutrigenomic targeting of carbohydrate craving behavior
T2 - Can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?
AU - Downs, B. William
AU - Chen, Amanda L.C.
AU - Chen, Thomas J.H.
AU - Waite, Roger L.
AU - Braverman, Eric R.
AU - Kerner, Mallory
AU - Braverman, Dasha
AU - Rhoades, Patrick
AU - Prihoda, Thomas J.
AU - Palomo, Tomas
AU - Oscar-Berman, Marlene
AU - Reinking, Jeffrey
AU - Blum, Seth H.
AU - DiNubile, Nicholas A.
AU - Liu, H. H.
AU - Blum, Kenneth
N1 - Funding Information:
The authors would like to thank the staff at Path Research & Medical Foundation, New York as well financial support. The writing of this review was supported in part by funds from the US Department of Health and Human Services, NIAAA (R01-AA07112 and K05-AA00219) and the Medical Research Service of the US Department of Veterans Affairs to Marlene Oscar-Berman.
PY - 2009/9
Y1 - 2009/9
N2 - Genetic mediated physiological processes that rely on both pharmacological and nutritional principles hold great promise for the successful therapeutic targeting of reduced carbohydrate craving, body-friendly fat loss, healthy body recomposition, and overall wellness. By integrating an assembly of scientific knowledge on inheritable characteristics and environmental mediators of gene expression, we review the relationship of genes, hormones, neurotransmitters, and nutrients as they correct unwanted weight gain coupled with unhappiness. In contrast to a simple one-locus, one-mechanism focus on pharmaceuticals alone, we hypothesize that the use of nutrigenomic treatment targeting multi-physiological neurological, immunological, and metabolic pathways will enable clinicians to intercede in the process of lipogenesis by promoting lipolysis while attenuating aberrant glucose cravings. In turn, this approach will enhance wellness in a safe and predictable manner through the use of a Genetic Positioning System (GPS) Map. The GPS Map, while presently incomplete, ultimately will serve not only as a blueprint for personalized medicine in the treatment of obesity, but also for the development of strategies for reducing many harmful addictive behaviors and promoting optimal health by using substances compatible with the body's immune system.
AB - Genetic mediated physiological processes that rely on both pharmacological and nutritional principles hold great promise for the successful therapeutic targeting of reduced carbohydrate craving, body-friendly fat loss, healthy body recomposition, and overall wellness. By integrating an assembly of scientific knowledge on inheritable characteristics and environmental mediators of gene expression, we review the relationship of genes, hormones, neurotransmitters, and nutrients as they correct unwanted weight gain coupled with unhappiness. In contrast to a simple one-locus, one-mechanism focus on pharmaceuticals alone, we hypothesize that the use of nutrigenomic treatment targeting multi-physiological neurological, immunological, and metabolic pathways will enable clinicians to intercede in the process of lipogenesis by promoting lipolysis while attenuating aberrant glucose cravings. In turn, this approach will enhance wellness in a safe and predictable manner through the use of a Genetic Positioning System (GPS) Map. The GPS Map, while presently incomplete, ultimately will serve not only as a blueprint for personalized medicine in the treatment of obesity, but also for the development of strategies for reducing many harmful addictive behaviors and promoting optimal health by using substances compatible with the body's immune system.
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U2 - 10.1016/j.mehy.2009.02.037
DO - 10.1016/j.mehy.2009.02.037
M3 - Article
C2 - 19450935
AN - SCOPUS:67649961275
VL - 73
SP - 427
EP - 434
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 3
ER -