Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus

Jeffrey S. Gilbert, Stephen P. Ford, A. Lee Lang, Lindsay R. Pahl, Mark C. Drumhiller, Sara A. Babcock, Peter W. Nathanielsz, Mark J Nijland

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Inadequate nutrition compromises fetal development and poses long-term health risks for the offspring, even without decreased birth weight. The present study sought to 1) establish the ontogeny of fetal renal glomerulus number (GN) in sheep and 2) evaluate the effects of 50% global nutrient restriction (NR) during early to midgestation on GN and the renin-angiotensin system in the fetal kidney. GN increased from 78 dG (68,560 ± 3802) to 135 dG (586,118 ± 25,792). NR increased combined kidney weight (29 ± 0.6 g versus 23 ± 1.1 g), whereas decreased GN relative to right kidney weight approached significance in males (26,000 ± 5300 versus 39,000 ± 2800 GN/g) compared with control (C) males and females. NR decreased immunoreactive angiotensin II (Ang II) type 1 receptor (AT1) in the NR kidneys at 78 dG and increased renin at 135 dG. Immunoreactive renin decreased from 78 to 135 dG. Female fetuses had more immunoreactive Ang II type 2 receptor (AT2) than male fetuses at 78 dG and males had more AT1 at 135 dG. The present study demonstrates gender-specific differences in fetal growth and development and in fetal kidney development in pregnancies affected by NR.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalPediatric Research
Volume61
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Sheep
Fetus
Fetal Development
Kidney
Food
Renin
Angiotensin Type 2 Receptor
Weights and Measures
Angiotensin Type 1 Receptor
Renin-Angiotensin System
Growth and Development
Birth Weight
Pregnancy
Health

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus. / Gilbert, Jeffrey S.; Ford, Stephen P.; Lang, A. Lee; Pahl, Lindsay R.; Drumhiller, Mark C.; Babcock, Sara A.; Nathanielsz, Peter W.; Nijland, Mark J.

In: Pediatric Research, Vol. 61, No. 1, 01.2007, p. 42-47.

Research output: Contribution to journalArticle

Gilbert, JS, Ford, SP, Lang, AL, Pahl, LR, Drumhiller, MC, Babcock, SA, Nathanielsz, PW & Nijland, MJ 2007, 'Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus', Pediatric Research, vol. 61, no. 1, pp. 42-47. https://doi.org/10.1203/01.pdr.0000250208.09874.91
Gilbert, Jeffrey S. ; Ford, Stephen P. ; Lang, A. Lee ; Pahl, Lindsay R. ; Drumhiller, Mark C. ; Babcock, Sara A. ; Nathanielsz, Peter W. ; Nijland, Mark J. / Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus. In: Pediatric Research. 2007 ; Vol. 61, No. 1. pp. 42-47.
@article{9ece4976fcb54c0894cab9a75955e5e0,
title = "Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus",
abstract = "Inadequate nutrition compromises fetal development and poses long-term health risks for the offspring, even without decreased birth weight. The present study sought to 1) establish the ontogeny of fetal renal glomerulus number (GN) in sheep and 2) evaluate the effects of 50{\%} global nutrient restriction (NR) during early to midgestation on GN and the renin-angiotensin system in the fetal kidney. GN increased from 78 dG (68,560 ± 3802) to 135 dG (586,118 ± 25,792). NR increased combined kidney weight (29 ± 0.6 g versus 23 ± 1.1 g), whereas decreased GN relative to right kidney weight approached significance in males (26,000 ± 5300 versus 39,000 ± 2800 GN/g) compared with control (C) males and females. NR decreased immunoreactive angiotensin II (Ang II) type 1 receptor (AT1) in the NR kidneys at 78 dG and increased renin at 135 dG. Immunoreactive renin decreased from 78 to 135 dG. Female fetuses had more immunoreactive Ang II type 2 receptor (AT2) than male fetuses at 78 dG and males had more AT1 at 135 dG. The present study demonstrates gender-specific differences in fetal growth and development and in fetal kidney development in pregnancies affected by NR.",
author = "Gilbert, {Jeffrey S.} and Ford, {Stephen P.} and Lang, {A. Lee} and Pahl, {Lindsay R.} and Drumhiller, {Mark C.} and Babcock, {Sara A.} and Nathanielsz, {Peter W.} and Nijland, {Mark J}",
year = "2007",
month = "1",
doi = "10.1203/01.pdr.0000250208.09874.91",
language = "English (US)",
volume = "61",
pages = "42--47",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus

AU - Gilbert, Jeffrey S.

AU - Ford, Stephen P.

AU - Lang, A. Lee

AU - Pahl, Lindsay R.

AU - Drumhiller, Mark C.

AU - Babcock, Sara A.

AU - Nathanielsz, Peter W.

AU - Nijland, Mark J

PY - 2007/1

Y1 - 2007/1

N2 - Inadequate nutrition compromises fetal development and poses long-term health risks for the offspring, even without decreased birth weight. The present study sought to 1) establish the ontogeny of fetal renal glomerulus number (GN) in sheep and 2) evaluate the effects of 50% global nutrient restriction (NR) during early to midgestation on GN and the renin-angiotensin system in the fetal kidney. GN increased from 78 dG (68,560 ± 3802) to 135 dG (586,118 ± 25,792). NR increased combined kidney weight (29 ± 0.6 g versus 23 ± 1.1 g), whereas decreased GN relative to right kidney weight approached significance in males (26,000 ± 5300 versus 39,000 ± 2800 GN/g) compared with control (C) males and females. NR decreased immunoreactive angiotensin II (Ang II) type 1 receptor (AT1) in the NR kidneys at 78 dG and increased renin at 135 dG. Immunoreactive renin decreased from 78 to 135 dG. Female fetuses had more immunoreactive Ang II type 2 receptor (AT2) than male fetuses at 78 dG and males had more AT1 at 135 dG. The present study demonstrates gender-specific differences in fetal growth and development and in fetal kidney development in pregnancies affected by NR.

AB - Inadequate nutrition compromises fetal development and poses long-term health risks for the offspring, even without decreased birth weight. The present study sought to 1) establish the ontogeny of fetal renal glomerulus number (GN) in sheep and 2) evaluate the effects of 50% global nutrient restriction (NR) during early to midgestation on GN and the renin-angiotensin system in the fetal kidney. GN increased from 78 dG (68,560 ± 3802) to 135 dG (586,118 ± 25,792). NR increased combined kidney weight (29 ± 0.6 g versus 23 ± 1.1 g), whereas decreased GN relative to right kidney weight approached significance in males (26,000 ± 5300 versus 39,000 ± 2800 GN/g) compared with control (C) males and females. NR decreased immunoreactive angiotensin II (Ang II) type 1 receptor (AT1) in the NR kidneys at 78 dG and increased renin at 135 dG. Immunoreactive renin decreased from 78 to 135 dG. Female fetuses had more immunoreactive Ang II type 2 receptor (AT2) than male fetuses at 78 dG and males had more AT1 at 135 dG. The present study demonstrates gender-specific differences in fetal growth and development and in fetal kidney development in pregnancies affected by NR.

UR - http://www.scopus.com/inward/record.url?scp=33846958081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846958081&partnerID=8YFLogxK

U2 - 10.1203/01.pdr.0000250208.09874.91

DO - 10.1203/01.pdr.0000250208.09874.91

M3 - Article

C2 - 17211139

AN - SCOPUS:33846958081

VL - 61

SP - 42

EP - 47

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1

ER -