Nucleolar G1 antigens as cancer targets

H. Busch, R. K. Busch, J. W. Freeman, A. Black, E. Rabinovsky, A. Chatterjee, A. B. Reddy, M. Yaneva

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Abstract

Cancer cells and most normal resting cells have been readily differentiated for a century by morphologic and biologic criteria but biochemical and immunologic distinctions have not yet withstood the test of time. Although Warburg et al. had indicated that biochemical differences in glycolysis existed between cancer cells and other cells, it took almost 30 years to establish that these differences applied only to a limited spectrum of tumors. Moreover, careful analysis of the enzymes and substrates of glycolysis, the Krebs cycle, and hydrogen transport did not provide meaningful differences between cancer cells and other cells. Isozyme variants, particularly fetal isozymes in cancer tissues, were reported, but results were variable in different studies and different tumors, as now found for 'oncogenes'.

Original languageEnglish (US)
Pages (from-to)141-151
Number of pages11
JournalJournal of Tumor Marker Oncology
Volume2
Issue number3
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Cancer Research

Cite this

Busch, H., Busch, R. K., Freeman, J. W., Black, A., Rabinovsky, E., Chatterjee, A., Reddy, A. B., & Yaneva, M. (1987). Nucleolar G1 antigens as cancer targets. Journal of Tumor Marker Oncology, 2(3), 141-151.