Nuclear hormone receptors in parasitic helminths

Wenjie Wu, Philip T Loverde

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nuclear receptors (NRs) belong to a large protein superfamily that are important transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume334
Issue number1-2
DOIs
StatePublished - Mar 1 2011

Fingerprint

Helminths
Cytoplasmic and Nuclear Receptors
Genes
Platyhelminths
Nematoda
Gene Duplication
Arthropods
Modulators
Proteins

Keywords

  • Ecdysozoa
  • Helminths
  • Lophotrochozoa
  • Nematoda
  • Nuclear receptors
  • Platyhelminths

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Nuclear hormone receptors in parasitic helminths. / Wu, Wenjie; Loverde, Philip T.

In: Molecular and Cellular Endocrinology, Vol. 334, No. 1-2, 01.03.2011, p. 56-66.

Research output: Contribution to journalArticle

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