Nuclear hormone receptors in parasitic helminths

Wenjie Wu, Philip T. LoVerde

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Nuclear receptors (NRs) belong to a large protein superfamily that are important transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume334
Issue number1-2
DOIs
StatePublished - Mar 1 2011

Keywords

  • Ecdysozoa
  • Helminths
  • Lophotrochozoa
  • Nematoda
  • Nuclear receptors
  • Platyhelminths

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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