Nuclear envelope proteins: Identification of lamin B subtypes

Keith R. Shelton, Patsy M. Egle, David L. Cochran

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The lamins are a group of nuclear envelope proteins thought to form a structural layer at the nuclear periphery. Lamins A, B and C occur in many cell types although lamin C, a subtype of lamin A, is relatively decreased in chicken cells. A subtype of lamin B has been found in chicken cells. This subtype, called lamin B1, is slightly larger and more acidic than the quantitatively major subtype now called lamin B2. The lamin B subtypes have very similar primary sequences and share a distinctive topology. Two lamin B subtypes have not been observed in mammalian tissues but have been found in three avian tissues, erythrocytes of mature chickens and liver and erythrocytes of 11- to 13-day-old embryos. As these tissues differ widely in metabolic activity, both subtypes appear to be constitutive nuclear proteins.

Original languageEnglish (US)
Pages (from-to)975-981
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume103
Issue number3
DOIs
StatePublished - Dec 15 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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