Nuclear-cytoplasmic distribution of ions in the hepatocyte.

I. L. Cameron, K. E. Hunter, N. K. Smith

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


To determine if nuclear/cytoplasmic (N/C) gradients of ions exist in mammalian hepatocytes, as has been shown to exist in the amphibian oocyte, small pieces of mouse liver were cryofixed for energy dispersive X-ray microanalysis of Na, K and Cl in thin freeze-dried cryosections. Expressing the data on a dry weight basis showed small but significant N/C gradients for Na and K but not for Cl. When the data were expressed on a wet weight basis no significant N/C gradients of Na, K or Cl were revealed. Questions of data interpretation are discussed.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalPhysiological Chemistry and Physics and Medical NMR
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Physiology
  • Spectroscopy


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