TY - JOUR
T1 - Nuclear and Cytoplasmic Inclusion Bodies in Pinealocytes of the Cotton Rat, Sigmodon hispidus
T2 - An Electron Microscopic Study
AU - Matsushima, Shoji
AU - Sakai, Yuko
AU - Aida, Ichiro
AU - Reiter, Russel J.
PY - 1984/7
Y1 - 1984/7
N2 - Electron microscopic observations on pinealocytes of cotton rats (Sigmodon hispidus) killed in October revealed the presence of cytoplasmic inclusion bodies (CIBs) and two kinds of nuclear inclusions—coiled bodies and granular inclusion bodies. These inclusions were usually not bounded by a membrane. CIBs showed round or irregular profiles and consisted of granular and filamentous materials of moderate electron opacity intermingled with electron‐lucent areas. Nuclear granular inclusions appeared as homogeneous or heterogeneous granules of variable electron opacity, which usually exhibited round profiles of variable diameters and consisted of granular and filamentous elements. Electron‐opaque granules were observed in perinuclear spaces, dilated cisternae of rough endoplasmic reticulum, as well as in the central portion of CIBs. In CIBs containing granules, the peripheral region was composed of the moderately electron‐opaque substance seen in usual CIBs, while the central core was occupied by a granular and filamentous substance and an intervening electron‐lucent matrix. Since an electron‐opaque granular substance in nuclei, perinuclear spaces, cisternae of rough endoplasmic reticulum, and the central portion of CIBs may occur concomitantly, the granules seen in these sites may be related. Coiled bodies were round in profile and were composed of electron‐opaque strands consisting of granular and filamentous elements and intervening material of low electron opacity. This structure, frequently located in close proximity to the nuclear granular inclusions, may play a role in the formation of the intranuclear granules in cotton rat pinealocytes.
AB - Electron microscopic observations on pinealocytes of cotton rats (Sigmodon hispidus) killed in October revealed the presence of cytoplasmic inclusion bodies (CIBs) and two kinds of nuclear inclusions—coiled bodies and granular inclusion bodies. These inclusions were usually not bounded by a membrane. CIBs showed round or irregular profiles and consisted of granular and filamentous materials of moderate electron opacity intermingled with electron‐lucent areas. Nuclear granular inclusions appeared as homogeneous or heterogeneous granules of variable electron opacity, which usually exhibited round profiles of variable diameters and consisted of granular and filamentous elements. Electron‐opaque granules were observed in perinuclear spaces, dilated cisternae of rough endoplasmic reticulum, as well as in the central portion of CIBs. In CIBs containing granules, the peripheral region was composed of the moderately electron‐opaque substance seen in usual CIBs, while the central core was occupied by a granular and filamentous substance and an intervening electron‐lucent matrix. Since an electron‐opaque granular substance in nuclei, perinuclear spaces, cisternae of rough endoplasmic reticulum, and the central portion of CIBs may occur concomitantly, the granules seen in these sites may be related. Coiled bodies were round in profile and were composed of electron‐opaque strands consisting of granular and filamentous elements and intervening material of low electron opacity. This structure, frequently located in close proximity to the nuclear granular inclusions, may play a role in the formation of the intranuclear granules in cotton rat pinealocytes.
KW - cotton rat (Sigmodon btspidus)
KW - nuclear and cytoplasmic inclusion bodies
KW - pineal gland
KW - ultrastructure
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U2 - 10.1111/j.1600-079X.1984.tb00220.x
DO - 10.1111/j.1600-079X.1984.tb00220.x
M3 - Article
C2 - 6100722
AN - SCOPUS:0021735735
VL - 1
SP - 293
EP - 304
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 3
ER -