Abstract
Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22phox mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.
Original language | English (US) |
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Pages (from-to) | 541-543 |
Number of pages | 3 |
Journal | Kidney international |
Volume | 83 |
Issue number | 4 |
DOIs |
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State | Published - Apr 2013 |
ASJC Scopus subject areas
- Nephrology