Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

Yves Gorin

Research output: Contribution to journalComment/debate

21 Scopus citations

Abstract

Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22phox mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalKidney international
Volume83
Issue number4
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease'. Together they form a unique fingerprint.

  • Cite this