Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

Yves Gorin

doi:10.1038/ki.2012.434

Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

Yves Gorin

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

22 Scopus citations

Abstract

Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22_phox mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.

Original language	English (US)
Pages (from-to)	541-543
Number of pages	3
Journal	Kidney international
Volume	83
Issue number	4
DOIs	https://doi.org/10.1038/ki.2012.434
State	Published - Apr 2013

ASJC Scopus subject areas

Nephrology

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abstract = "Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22phox mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.",

author = "Yves Gorin",

note = "Funding Information: The author is supported by Juvenile Diabetes Research Foundation Multiproject Grants and National Institutes of Health grant RO1 DK 079996.",

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AB - Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22phox mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.

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Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

Abstract

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