TY - JOUR
T1 - Nox4 and diabetic nephropathy
T2 - With a friend like this, who needs enemies?
AU - Gorin, Yves
AU - Block, Karen
N1 - Funding Information:
This work was supported by Juvenile Diabetes Research Foundation Multiproject Grants (Y.G. and K.B.), NIH RO1 DK 079996 (Y.G.), NIH RO1 CA 131272 (K.B.), and the Veterans Administration (K.B.).
PY - 2013
Y1 - 2013
N2 - Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, a complication of diabetes in the kidney. NADPH oxidases of the Nox family are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current understanding of the roles of Nox catalytic and regulatory subunits in the processes that control mesangial cell, podocyte, and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin-angiotensin system and transforming growth factor-β. The role of the Nox isoform Nox4 in the redox processes that alter renal biology in diabetes is highlighted.
AB - Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, a complication of diabetes in the kidney. NADPH oxidases of the Nox family are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current understanding of the roles of Nox catalytic and regulatory subunits in the processes that control mesangial cell, podocyte, and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin-angiotensin system and transforming growth factor-β. The role of the Nox isoform Nox4 in the redox processes that alter renal biology in diabetes is highlighted.
KW - Diabetic complications
KW - Diabetic nephropathy
KW - Free radicals
KW - Glomerular cell injury
KW - Hyperglycemia
KW - NADPH oxidases of the Nox family
KW - Nox4
KW - Oxidative stress
KW - Reactive oxygen species
KW - Tubulointerstitial cell injury
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U2 - 10.1016/j.freeradbiomed.2013.03.014
DO - 10.1016/j.freeradbiomed.2013.03.014
M3 - Review article
C2 - 23528476
AN - SCOPUS:84877046009
VL - 61
SP - 130
EP - 142
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
ER -