Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?

Yves Gorin, Karen Block

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, a complication of diabetes in the kidney. NADPH oxidases of the Nox family are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current understanding of the roles of Nox catalytic and regulatory subunits in the processes that control mesangial cell, podocyte, and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin-angiotensin system and transforming growth factor-β. The role of the Nox isoform Nox4 in the redox processes that alter renal biology in diabetes is highlighted.

Original languageEnglish (US)
Pages (from-to)130-142
Number of pages13
JournalFree Radical Biology and Medicine
Volume61
DOIs
StatePublished - 2013

Keywords

  • Diabetic complications
  • Diabetic nephropathy
  • Free radicals
  • Glomerular cell injury
  • Hyperglycemia
  • NADPH oxidases of the Nox family
  • Nox4
  • Oxidative stress
  • Reactive oxygen species
  • Tubulointerstitial cell injury

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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