Novel tumor necrosis factor-knockout mice that lack Peyer's patches

Dmitry V. Kuprash, Alexei V. Tumanov, Dmitry J. Liepinsh, Ekaterina P. Koroleva, Marina S. Drutskaya, Andrei A. Kruglov, Alexander N. Shakhov, Eileen Southon, William J. Murphy, Lino Tessarollo, Sergei I. Grivennikov, Sergei A. Nedospasov

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.

Original languageEnglish (US)
Pages (from-to)1592-1600
Number of pages9
JournalEuropean Journal of Immunology
Volume35
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

Keywords

  • Cytokines
  • Host defense
  • Lymphoid organ development

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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