Novel tumor necrosis factor-knockout mice that lack Peyer's patches

Dmitry V. Kuprash, Alexei V Tumanov, Dmitry J. Liepinsh, Ekaterina P. Koroleva, Marina S. Drutskaya, Andrei A. Kruglov, Alexander N. Shakhov, Eileen Southon, William J. Murphy, Lino Tessarollo, Sergei I. Grivennikov, Sergei A. Nedospasov

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.

Original languageEnglish (US)
Pages (from-to)1592-1600
Number of pages9
JournalEuropean Journal of Immunology
Volume35
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Peyer's Patches
Knockout Mice
Tumor Necrosis Factor-alpha
Receptors, Tumor Necrosis Factor, Type I
Listeriosis
Mutation
Organogenesis
Immune System Diseases
Lymph Nodes
Technology

Keywords

  • Cytokines
  • Host defense
  • Lymphoid organ development

ASJC Scopus subject areas

  • Immunology

Cite this

Kuprash, D. V., Tumanov, A. V., Liepinsh, D. J., Koroleva, E. P., Drutskaya, M. S., Kruglov, A. A., ... Nedospasov, S. A. (2005). Novel tumor necrosis factor-knockout mice that lack Peyer's patches. European Journal of Immunology, 35(5), 1592-1600. https://doi.org/10.1002/eji.200526119

Novel tumor necrosis factor-knockout mice that lack Peyer's patches. / Kuprash, Dmitry V.; Tumanov, Alexei V; Liepinsh, Dmitry J.; Koroleva, Ekaterina P.; Drutskaya, Marina S.; Kruglov, Andrei A.; Shakhov, Alexander N.; Southon, Eileen; Murphy, William J.; Tessarollo, Lino; Grivennikov, Sergei I.; Nedospasov, Sergei A.

In: European Journal of Immunology, Vol. 35, No. 5, 01.05.2005, p. 1592-1600.

Research output: Contribution to journalArticle

Kuprash, DV, Tumanov, AV, Liepinsh, DJ, Koroleva, EP, Drutskaya, MS, Kruglov, AA, Shakhov, AN, Southon, E, Murphy, WJ, Tessarollo, L, Grivennikov, SI & Nedospasov, SA 2005, 'Novel tumor necrosis factor-knockout mice that lack Peyer's patches', European Journal of Immunology, vol. 35, no. 5, pp. 1592-1600. https://doi.org/10.1002/eji.200526119
Kuprash DV, Tumanov AV, Liepinsh DJ, Koroleva EP, Drutskaya MS, Kruglov AA et al. Novel tumor necrosis factor-knockout mice that lack Peyer's patches. European Journal of Immunology. 2005 May 1;35(5):1592-1600. https://doi.org/10.1002/eji.200526119
Kuprash, Dmitry V. ; Tumanov, Alexei V ; Liepinsh, Dmitry J. ; Koroleva, Ekaterina P. ; Drutskaya, Marina S. ; Kruglov, Andrei A. ; Shakhov, Alexander N. ; Southon, Eileen ; Murphy, William J. ; Tessarollo, Lino ; Grivennikov, Sergei I. ; Nedospasov, Sergei A. / Novel tumor necrosis factor-knockout mice that lack Peyer's patches. In: European Journal of Immunology. 2005 ; Vol. 35, No. 5. pp. 1592-1600.
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