Novel Therapies on the Horizon

Timothy P. Cripe, Kellie B. Haworth, Peter J. Houghton

Research output: Chapter in Book/Report/Conference proceedingChapter


As many of the prior chapters illustrate, we have had many successes in the treatment of children with malignant bone tumors. Nevertheless, there is a substantial fraction of patients who are not cured by current therapies. In addition, even those who are long term survivors often suffer chronic side effects of treatment. Thus, we need to continue to explore novel therapies both to increase the cure rates and decrease complications. In this chapter we review available data for a variety of new therapies including novel small molecules, immunotherapies, and virotherapy, with an emphasis on fi ndings in preclinical models or early phase clinical trials in patients with bone cancers.

Original languageEnglish (US)
Title of host publicationPediatric Oncology
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages27
StatePublished - 2015
Externally publishedYes

Publication series

NamePediatric Oncology
ISSN (Print)1613-5318
ISSN (Electronic)2191-0812

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology


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