Novel protein glycan-derived markers of systemic inf lammation and c-reactive protein in relation to glycemia, insulin resistance, and insulin secretion

Carlos Lorenzo, Andreas Festa, Anthony J. Hanley, Marian J. Rewers, Agustin Escalante, Steven M. Haffner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE N-Acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, and C-reactive protein (CRP) to direct measures of insulin sensitivity (insulin sensitivity index [SI]) and insulin secretion (acute insulin response [AIR]). RESEARCH DESIGN AND METHODS This study used cross-sectional analyses and included 1,225 participants with and without type 2 diabetes in the Insulin Resistance Atherosclerosis Study (IRAS). SI and AIR were measured using the frequently sampled intravenous glucose tolerance test, and GlycA and GlycB were measured using nuclear magnetic resonance spectroscopy. RESULTS GlycA and GlycB had a strong correlation with CRP (r = 0.60 [P < 0.001] and r = 0.46 [P < 0.001], respectively). In a linear regression model with both GlycA and CRP as independent variables, GlycA (b31 SD,20.0460.02; P < 0.01) and CRP (20.066 0.02; P < 0.001) were independently associated with SI even after adjusting for demographics, smoking, physical activity, plasma glucose, and BMI. However, neither CRP nor GlycA had an independent relationship with AIR. CONCLUSIONS GlycAmay complement CRP in evaluating the relationship between inflammation, glucose tolerance, and insulin resistance .

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalDiabetes Care
Volume40
Issue number3
DOIs
StatePublished - Mar 1 2017

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C-Reactive Protein
Polysaccharides
Insulin Resistance
Insulin
Proteins
Linear Models
Inflammation
Glucose
Galactosamine
Acetylglucosamine
N-Acetylneuraminic Acid
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Atherosclerosis
Complement System Proteins
Research Design
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Smoking
Demography

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Novel protein glycan-derived markers of systemic inf lammation and c-reactive protein in relation to glycemia, insulin resistance, and insulin secretion. / Lorenzo, Carlos; Festa, Andreas; Hanley, Anthony J.; Rewers, Marian J.; Escalante, Agustin; Haffner, Steven M.

In: Diabetes Care, Vol. 40, No. 3, 01.03.2017, p. 375-382.

Research output: Contribution to journalArticle

Lorenzo, Carlos ; Festa, Andreas ; Hanley, Anthony J. ; Rewers, Marian J. ; Escalante, Agustin ; Haffner, Steven M. / Novel protein glycan-derived markers of systemic inf lammation and c-reactive protein in relation to glycemia, insulin resistance, and insulin secretion. In: Diabetes Care. 2017 ; Vol. 40, No. 3. pp. 375-382.
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N2 - OBJECTIVE N-Acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, and C-reactive protein (CRP) to direct measures of insulin sensitivity (insulin sensitivity index [SI]) and insulin secretion (acute insulin response [AIR]). RESEARCH DESIGN AND METHODS This study used cross-sectional analyses and included 1,225 participants with and without type 2 diabetes in the Insulin Resistance Atherosclerosis Study (IRAS). SI and AIR were measured using the frequently sampled intravenous glucose tolerance test, and GlycA and GlycB were measured using nuclear magnetic resonance spectroscopy. RESULTS GlycA and GlycB had a strong correlation with CRP (r = 0.60 [P < 0.001] and r = 0.46 [P < 0.001], respectively). In a linear regression model with both GlycA and CRP as independent variables, GlycA (b31 SD,20.0460.02; P < 0.01) and CRP (20.066 0.02; P < 0.001) were independently associated with SI even after adjusting for demographics, smoking, physical activity, plasma glucose, and BMI. However, neither CRP nor GlycA had an independent relationship with AIR. CONCLUSIONS GlycAmay complement CRP in evaluating the relationship between inflammation, glucose tolerance, and insulin resistance .

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