Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation

D. J. Cohen, A. Cheng, A. Kahn, M. Aviram, A. J. Whitehead, S. L. Hyzy, R. M. Clohessy, B. D. Boyan, Zvi Schwartz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.

Original languageEnglish (US)
Article number20493
JournalScientific Reports
Volume6
DOIs
StatePublished - Feb 8 2016

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Tooth
Bone and Bones
Equipment and Supplies
Dental Implants
Osteogenesis
Osseointegration
X-Ray Microtomography
Inlays
Vanadium
Bone Regeneration
Angiogenesis Inducing Agents
Bone Development
Titanium
Aluminum
Osteoblasts
Tibia
Skull
Lasers
Rabbits

ASJC Scopus subject areas

  • General

Cite this

Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies : Design, Development And Implementation. / Cohen, D. J.; Cheng, A.; Kahn, A.; Aviram, M.; Whitehead, A. J.; Hyzy, S. L.; Clohessy, R. M.; Boyan, B. D.; Schwartz, Zvi.

In: Scientific Reports, Vol. 6, 20493, 08.02.2016.

Research output: Contribution to journalArticle

Cohen, D. J. ; Cheng, A. ; Kahn, A. ; Aviram, M. ; Whitehead, A. J. ; Hyzy, S. L. ; Clohessy, R. M. ; Boyan, B. D. ; Schwartz, Zvi. / Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies : Design, Development And Implementation. In: Scientific Reports. 2016 ; Vol. 6.
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