Novel 12-bp deletion in the coding region of the bovine NPM1 gene affects growth traits

Y. Z. Huang, E. P. Zhang, H. Chen, J. Wang, Z. J. Li, Y. T. Huai, L. Ma, X. Y. Lan, G. Ren, C. Z. Lei, X. T. Fang, J. Q. Wang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The nucleophosmin 1 gene (NPM1) encodes a multifunctional nucleolar phosphoprotein that plays a crucial role in the control of various aspects of cell growth and homeostasis. In this study, the coding region of the NPM1 gene was screened in 1035 individuals of 4 Chinese cattle breeds by DNA sequencing and polyacrylamide gel electrophoresis. A novel 12-bp deletion mutation was identified in the coding region of the NPM1 gene. The PCR products of primer NPM1-P2 exhibited 3 genotypes and 2 alleles: 178 bp (denoted as W) and 166 bp (denoted as D). Genotype DD and allele D were predominant in the studied populations. Association analysis with growth traits in the Nanyang breed (N = 265) showed that the animals with genotype DD had significantly greater birth weight, body weight, body length, and heart girth than those with genotype WD (P < 0.01 or P < 0.05) at birth and after 6 months and 12 months, but not at 18 and 24 months of age. Results of this study suggest that the NPM1 gene is a candidate gene for growth traits in cattle.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalJournal of Applied Genetics
Issue number2
StatePublished - 2010
Externally publishedYes


  • Cattle
  • Deletion mutation
  • Growth traits
  • NPM1 gene

ASJC Scopus subject areas

  • Genetics


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