Nothing can be coincidence: synaptic inhibition and plasticity in the cerebellar nuclei

Jason R. Pugh, Indira M. Raman

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Many cerebellar neurons fire spontaneously, generating 10-100 action potentials per second even without synaptic input. This high basal activity correlates with information-coding mechanisms that differ from those of cells that are quiescent until excited synaptically. For example, in the deep cerebellar nuclei, Hebbian patterns of coincident synaptic excitation and postsynaptic firing fail to induce long-term increases in the strength of excitatory inputs. Instead, excitatory synaptic currents are potentiated by combinations of inhibition and excitation that resemble the activity of Purkinje and mossy fiber afferents that is predicted to occur during cerebellar associative learning tasks. Such results indicate that circuits with intrinsically active neurons have rules for information transfer and storage that distinguish them from other brain regions.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalTrends in Neurosciences
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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