Nosocomial outbreak of Exophiala jeanselmei fungemia associated with contamination of hospital water

Marcio Nucci, Tiyomi Akiti, Gloria Barreiros, Fernanda Silveira, Sanjay G. Revankar, Brian L Wickes, Deanna A. Sutton, Thomas F Patterson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

From December 1996 through September 1997, we diagnosed 19 cases of fungemia due to Exophiala jeanselmei. We conducted a matched case-control study in which we cultured specimens of blood products, intravenous solutions, and water from a hospital water system. Isolates from environmental cultures were compared to those recovered from patients by random amplification of polymorphic DNA (RAPD). Multivariate analysis showed that neutropenia, longer duration of hospitalization, and use of corticosteroids were risk factors for infection. Environmental cultures yielded E. jeanselmei from 3 of 85 sources: deionized water from the hospital pharmacy, 1 water tank, and water from a sink in a non-patient care area. Use of deionized pharmacy water to prepare antiseptic solutions was discontinued, and no additional cases of infection occurred. RAPD typing showed that isolates from case patients and isolates from the pharmacy water were highly related, whereas the patterns of isolates recovered from the 2 other sources of water were distinct.

Original languageEnglish (US)
Pages (from-to)1475-1480
Number of pages6
JournalClinical Infectious Diseases
Volume34
Issue number11
DOIs
StatePublished - Jun 1 2002

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Exophiala
Fungemia
Disease Outbreaks
Water
Local Anti-Infective Agents
DNA Fingerprinting
Infection
Neutropenia
Case-Control Studies
Adrenal Cortex Hormones
Hospitalization
Multivariate Analysis

ASJC Scopus subject areas

  • Immunology

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Nosocomial outbreak of Exophiala jeanselmei fungemia associated with contamination of hospital water. / Nucci, Marcio; Akiti, Tiyomi; Barreiros, Gloria; Silveira, Fernanda; Revankar, Sanjay G.; Wickes, Brian L; Sutton, Deanna A.; Patterson, Thomas F.

In: Clinical Infectious Diseases, Vol. 34, No. 11, 01.06.2002, p. 1475-1480.

Research output: Contribution to journalArticle

Nucci, Marcio ; Akiti, Tiyomi ; Barreiros, Gloria ; Silveira, Fernanda ; Revankar, Sanjay G. ; Wickes, Brian L ; Sutton, Deanna A. ; Patterson, Thomas F. / Nosocomial outbreak of Exophiala jeanselmei fungemia associated with contamination of hospital water. In: Clinical Infectious Diseases. 2002 ; Vol. 34, No. 11. pp. 1475-1480.
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