Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion

R. A. DeFronzo, M. Goldberg, Z. S. Agus

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Four patients with chronic illnesses and stable hyponatremia and plasma hypotonicity had normal urinary diluting capacity, with excretion of > 80% of a standard water load (20 ml/kg) within 4 hours and maintenance of a urine osmolality < 100 mosmol/kg, during sustained water diuresis. Administration of a chronic salt load did not correct the hyponatremia. However, it was stabilized after treatment of the underlying medical condition. These subjects may represent a true resetting of the osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalAnnals of internal medicine
Volume84
Issue number5
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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