Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

Oludare B. Taiwo, I. Jon Russell, Emmanuel Mignot, Ling Lin, Joel E. Michalek, Wanda Haynes, Yangming Xiao, Jamie M. Zeitzer, Alice A. Larson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities. Methods: We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence. Results: Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls. Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalSleep Medicine
Volume8
Issue number3
DOIs
StatePublished - Apr 1 2007

Keywords

  • CSF
  • Clinical trial
  • Fibromyalgia
  • Hypocretin-1
  • Orexin-A
  • Sleep

ASJC Scopus subject areas

  • Medicine(all)

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