Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state

Shawn R. Gray, Liang Ye, Jing Yong Ye, Martin Paukert

Research output: Contribution to journalArticlepeer-review

Abstract

Recent years have seen compelling demonstrations of the importance of behavioral state on sensory processing and attention. Arousal plays a dominant role in controlling brain-wide neural activity patterns, particularly through modulation by norepinephrine. Noradrenergic brainstem nuclei, including locus coeruleus, can be activated by stimuli of multiple sensory modalities and broadcast modulatory signals via axonal projections throughout the brain. This organization might suggest proportional brain-wide norepinephrine release during states of heightened vigilance. Here, however, we have found that low-intensity, nonarousing visual stimuli enhanced vigilance-dependent noradrenergic signaling locally in visual cortex, revealed using dual-site fiber photometry to monitor noradrenergic Ca2+responses of astroglia simultaneously in cerebellum and visual cortex and two-photon microscopy to monitor noradrenergic axonal terminal Ca2+dynamics. Nitric oxide, following N-methyl-d-aspartate receptor activation in neuronal nitric oxide synthase-positive interneurons, mediated transient acceleration of norepinephrinedependent astroglia Ca2+activation. These findings reveal a candidate cortical microcircuit for sensory modalityselective modulation of attention.

Original languageEnglish (US)
Article numbereabk1378
JournalScience Advances
Volume7
Issue number51
DOIs
StatePublished - Dec 2021

ASJC Scopus subject areas

  • General

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