Noradrenaline induces nonshivering thermogenesis in both the naked mole-rat (Heterocephalus glaber) and the Damara mole-rat (Cryptomys damarensis) despite very different modes of thermoregulation

Michael S. Hislop, Rochelle Buffenstein

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

1. 1. An important component of endothermy in small mammals is achieved by the employment of nonshivering thermogenesis (NST). 2. 2. Nonshivering thermogenic abilities of two subterranean mammals, the Damara mole-rat (Cryptomys damarensis) and the naked mole-rat (Heterocephalus glaber), were assessed by administering noradrenaline (0.8 mg/kg) to anaesthetized animals. These two species show very different modes of thermoregulation in that the former regulates body temperature whereas in the latter species body temperature closely tracks ambient temperature. 3. 3. Both species showed the characteristic NST response by significantly increasing metabolic rate (C. damarensis), 194 ± 57%; H. glaber, 356 ± 199%) and body temperature (C. damarensis, 4.1 ± 0.5°C; H. glaber, 2.8 ± 0.9°C) with noradrenaline intervention. 4. 4. These animals can therefore employ endothermy. While the Damara mole-rat conforms to mammalian thermoregulatory dogma and is homeothermic, the naked mole-rat may by definition be an 'endothermic poikilotherm'.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalJournal of Thermal Biology
Volume19
Issue number1
DOIs
StatePublished - Feb 1994

Keywords

  • Cryptomys damarensis
  • Damara mole-rat
  • Heterocephalus glaber
  • Noradrenaline
  • endothermy
  • naked mole-rat
  • nonshivering thermogenesis
  • poikilotherm

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

Fingerprint Dive into the research topics of 'Noradrenaline induces nonshivering thermogenesis in both the naked mole-rat (Heterocephalus glaber) and the Damara mole-rat (Cryptomys damarensis) despite very different modes of thermoregulation'. Together they form a unique fingerprint.

Cite this