Noradrenaline induces nonshivering thermogenesis in both the naked mole-rat (Heterocephalus glaber) and the Damara mole-rat (Cryptomys damarensis) despite very different modes of thermoregulation

Michael S. Hislop, Rochelle Buffenstein

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

1. 1. An important component of endothermy in small mammals is achieved by the employment of nonshivering thermogenesis (NST). 2. 2. Nonshivering thermogenic abilities of two subterranean mammals, the Damara mole-rat (Cryptomys damarensis) and the naked mole-rat (Heterocephalus glaber), were assessed by administering noradrenaline (0.8 mg/kg) to anaesthetized animals. These two species show very different modes of thermoregulation in that the former regulates body temperature whereas in the latter species body temperature closely tracks ambient temperature. 3. 3. Both species showed the characteristic NST response by significantly increasing metabolic rate (C. damarensis), 194 ± 57%; H. glaber, 356 ± 199%) and body temperature (C. damarensis, 4.1 ± 0.5°C; H. glaber, 2.8 ± 0.9°C) with noradrenaline intervention. 4. 4. These animals can therefore employ endothermy. While the Damara mole-rat conforms to mammalian thermoregulatory dogma and is homeothermic, the naked mole-rat may by definition be an 'endothermic poikilotherm'.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalJournal of Thermal Biology
Volume19
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Mole Rats
Heterocephalus glaber
Cryptomys
mole rats
Thermogenesis
Body Temperature Regulation
thermoregulation
heat production
norepinephrine
Rats
Norepinephrine
Mammals
body temperature
Body Temperature
Animals
Temperature
small mammals
ambient temperature
animals
mammals

Keywords

  • Cryptomys damarensis
  • Damara mole-rat
  • endothermy
  • Heterocephalus glaber
  • naked mole-rat
  • nonshivering thermogenesis
  • Noradrenaline
  • poikilotherm

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

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title = "Noradrenaline induces nonshivering thermogenesis in both the naked mole-rat (Heterocephalus glaber) and the Damara mole-rat (Cryptomys damarensis) despite very different modes of thermoregulation",
abstract = "1. 1. An important component of endothermy in small mammals is achieved by the employment of nonshivering thermogenesis (NST). 2. 2. Nonshivering thermogenic abilities of two subterranean mammals, the Damara mole-rat (Cryptomys damarensis) and the naked mole-rat (Heterocephalus glaber), were assessed by administering noradrenaline (0.8 mg/kg) to anaesthetized animals. These two species show very different modes of thermoregulation in that the former regulates body temperature whereas in the latter species body temperature closely tracks ambient temperature. 3. 3. Both species showed the characteristic NST response by significantly increasing metabolic rate (C. damarensis), 194 ± 57{\%}; H. glaber, 356 ± 199{\%}) and body temperature (C. damarensis, 4.1 ± 0.5°C; H. glaber, 2.8 ± 0.9°C) with noradrenaline intervention. 4. 4. These animals can therefore employ endothermy. While the Damara mole-rat conforms to mammalian thermoregulatory dogma and is homeothermic, the naked mole-rat may by definition be an 'endothermic poikilotherm'.",
keywords = "Cryptomys damarensis, Damara mole-rat, endothermy, Heterocephalus glaber, naked mole-rat, nonshivering thermogenesis, Noradrenaline, poikilotherm",
author = "Hislop, {Michael S.} and Rochelle Buffenstein",
year = "1994",
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T1 - Noradrenaline induces nonshivering thermogenesis in both the naked mole-rat (Heterocephalus glaber) and the Damara mole-rat (Cryptomys damarensis) despite very different modes of thermoregulation

AU - Hislop, Michael S.

AU - Buffenstein, Rochelle

PY - 1994

Y1 - 1994

N2 - 1. 1. An important component of endothermy in small mammals is achieved by the employment of nonshivering thermogenesis (NST). 2. 2. Nonshivering thermogenic abilities of two subterranean mammals, the Damara mole-rat (Cryptomys damarensis) and the naked mole-rat (Heterocephalus glaber), were assessed by administering noradrenaline (0.8 mg/kg) to anaesthetized animals. These two species show very different modes of thermoregulation in that the former regulates body temperature whereas in the latter species body temperature closely tracks ambient temperature. 3. 3. Both species showed the characteristic NST response by significantly increasing metabolic rate (C. damarensis), 194 ± 57%; H. glaber, 356 ± 199%) and body temperature (C. damarensis, 4.1 ± 0.5°C; H. glaber, 2.8 ± 0.9°C) with noradrenaline intervention. 4. 4. These animals can therefore employ endothermy. While the Damara mole-rat conforms to mammalian thermoregulatory dogma and is homeothermic, the naked mole-rat may by definition be an 'endothermic poikilotherm'.

AB - 1. 1. An important component of endothermy in small mammals is achieved by the employment of nonshivering thermogenesis (NST). 2. 2. Nonshivering thermogenic abilities of two subterranean mammals, the Damara mole-rat (Cryptomys damarensis) and the naked mole-rat (Heterocephalus glaber), were assessed by administering noradrenaline (0.8 mg/kg) to anaesthetized animals. These two species show very different modes of thermoregulation in that the former regulates body temperature whereas in the latter species body temperature closely tracks ambient temperature. 3. 3. Both species showed the characteristic NST response by significantly increasing metabolic rate (C. damarensis), 194 ± 57%; H. glaber, 356 ± 199%) and body temperature (C. damarensis, 4.1 ± 0.5°C; H. glaber, 2.8 ± 0.9°C) with noradrenaline intervention. 4. 4. These animals can therefore employ endothermy. While the Damara mole-rat conforms to mammalian thermoregulatory dogma and is homeothermic, the naked mole-rat may by definition be an 'endothermic poikilotherm'.

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