Nonsteroidal anti-inflammatory drugs.

L. C. Knodel, M. K. Roush, T. L. Barton

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used medications today. Although their exact mechanism of action is unclear, inhibition of prostaglandin synthesis contributes significantly to their analgesic, anti-inflammatory, antipyretic, and antiplatelet effects. In recent years, additional mechanisms of action have been proposed for NSAIDs, and these may explain the variability commonly noted in patient response and tolerability to individual NSAIDs. NSAID therapy is not without risk, and serious adverse effects involving the gastrointestinal tract, kidneys, blood, and liver have been reported.

Original languageEnglish (US)
Pages (from-to)301-325
Number of pages25
JournalClinics in podiatric medicine and surgery
Issue number2
StatePublished - Apr 1 1992

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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