Nonspecific lymphocytic myocarditis in baboons is associated with Trypanosoma cruzi infection

Marcia C.R. Andrade, Edward J. Dick, Rodolfo Guardado-Mendoza, Michaelle L. Hohmann, Diana C.P. Mejido, John L. VandeBerg, Cheryl D. DiCarlo, Gene B. Hubbard

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    16 Scopus citations

    Abstract

    Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.

    Original languageEnglish (US)
    Pages (from-to)235-239
    Number of pages5
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume81
    Issue number2
    Publication statusPublished - Aug 1 2009

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    ASJC Scopus subject areas

    • Parasitology
    • Virology
    • Infectious Diseases

    Cite this

    Andrade, M. C. R., Dick, E. J., Guardado-Mendoza, R., Hohmann, M. L., Mejido, D. C. P., VandeBerg, J. L., ... Hubbard, G. B. (2009). Nonspecific lymphocytic myocarditis in baboons is associated with Trypanosoma cruzi infection. American Journal of Tropical Medicine and Hygiene, 81(2), 235-239.