TY - JOUR
T1 - Nonredundant function of soluble ltα3 produced by innate lymphoid cells in intestinal homeostasis
AU - Kruglov, Andrey A.
AU - Grivennikov, Sergei I.
AU - Kuprash, Dmitry V.
AU - Winsauer, Caroline
AU - Prepens, Sandra
AU - Seleznik, Gitta Maria
AU - Eberl, Gerard
AU - Littman, Dan R.
AU - Heikenwalder, Mathias
AU - Tumanov, Alexei V.
AU - Nedospasov, Sergei A.
PY - 2013
Y1 - 2013
N2 - Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin a (sLTα3) produced by RORγt+ innate lymphoid cells (ILCs) controls T cell -dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin β (LTα1β 2) produced by RORγt+ ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt+ cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.
AB - Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin a (sLTα3) produced by RORγt+ innate lymphoid cells (ILCs) controls T cell -dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin β (LTα1β 2) produced by RORγt+ ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt+ cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.
UR - https://www.scopus.com/pages/publications/84889247024
UR - https://www.scopus.com/pages/publications/84889247024#tab=citedBy
U2 - 10.1126/science.1243364
DO - 10.1126/science.1243364
M3 - Article
C2 - 24311691
AN - SCOPUS:84889247024
SN - 0036-8075
VL - 342
SP - 1243
EP - 1246
JO - Science
JF - Science
IS - 6163
ER -