TY - JOUR
T1 - Nonoxidative glucose consumption during focal physiologic neural activity
AU - Fox, Peter T.
AU - Raichle, Marcus E.
AU - Mintun, Mark A.
AU - Dence, Carmen
PY - 1988
Y1 - 1988
N2 - Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with positron emission tomography, and a resting-state molar ratio of oxygen to glucose consumption of 4.1:1 was obtained. Physiological neural activity, however, increased glucose uptake and blood flow much more (51 and 50 percent, respectively) than oxygen consumption (5 percent) and produced a molar ratio for the increases of 0.4:1. Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.
AB - Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with positron emission tomography, and a resting-state molar ratio of oxygen to glucose consumption of 4.1:1 was obtained. Physiological neural activity, however, increased glucose uptake and blood flow much more (51 and 50 percent, respectively) than oxygen consumption (5 percent) and produced a molar ratio for the increases of 0.4:1. Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.
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U2 - 10.1126/science.3260686
DO - 10.1126/science.3260686
M3 - Article
C2 - 3260686
AN - SCOPUS:0023780085
SN - 0036-8075
VL - 241
SP - 462
EP - 464
JO - Science
JF - Science
IS - 4864
ER -