Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex

Ai Ling Lin, Peter T Fox, Jean Hardies, Timothy Q. Duong, Jia Hong Gao

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The purpose of this study was to investigate activation-induced hypermetabolism and hyperemia by using a multifrequency (4, 8, and 16 Hz) reversing-checkerboard visual stimulation paradigm. Specifically, we sought to (i) quantify the relative contributions of the oxidative and nonoxidative metabolic pathways in meeting the increased energy demands [i.e., ATP production (JATP)] of task-induced neuronal activation and (ii) determine whether task-induced cerebral blood flow(CBF) augmentation was driven by oxidative or nonoxidative metabolic pathways. Focal increases in CBF, cerebral metabolic rate of oxygen (CMRO2; i.e., index of aerobic metabolism), and lactate production (JLac; i.e., index of anaerobic metabolism) were measured by using physiologically quantitative MRI and spectroscopy methods. Task-induced increases in JATP were small (12.2-16.7%) at all stimulation frequencies and were generated by aerobic metabolism (approximately 98%), with %ΔJATP being linearly correlated with the percentage change in CMRO2 (r = 1.00, P < 0.001). In contrast, taskinduced increases in CBF were large (51.7-65.1%) and negatively correlated with the percentage change in CMRO2 (r=-0.64,P=0.024),but positively correlated with %ΔJLac (r = 0.91, P < 0.001). These results indicate that (i) the energy demand of task-induced brain activation is small (approximately 15%) relative to the hyperemic response (approximately 60%), (ii) this energy demand is met through oxidative metabolism, and (iii) the CBF response is mediated by factors other than oxygen demand.

Original languageEnglish (US)
Pages (from-to)8446-8451
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number18
DOIs
StatePublished - May 4 2010

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Cerebrovascular Circulation
Visual Cortex
Oxygen Consumption
Adenosine Triphosphate
Metabolic Networks and Pathways
Oxygen
Anaerobiosis
Photic Stimulation
Hyperemia
Lactic Acid
Spectrum Analysis
Brain

Keywords

  • Cerebral metabolic rate of oxygen
  • Lactate production

ASJC Scopus subject areas

  • General

Cite this

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex. / Lin, Ai Ling; Fox, Peter T; Hardies, Jean; Duong, Timothy Q.; Gao, Jia Hong.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 18, 04.05.2010, p. 8446-8451.

Research output: Contribution to journalArticle

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