Nonlinear conductance-volume relationship for murine conductance catheter measurement system

Chia Ling Wei; Jonathan W. Valvano; Marc D. Feldman; John A. Pearce

doi:10.1109/TBME.2005.856029

Nonlinear conductance-volume relationship for murine conductance catheter measurement system

Chia Ling Wei, Jonathan W. Valvano, Marc D. Feldman, John A. Pearce

Medicine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.

Original language	English (US)
Pages (from-to)	1654-1661
Number of pages	8
Journal	IEEE Transactions on Biomedical Engineering
Volume	52
Issue number	10
DOIs	https://doi.org/10.1109/TBME.2005.856029
State	Published - Oct 2005

Keywords

Conductance catheter
Conductance-volume relationship
Volume estimation

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2005.856029

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@article{b8c645ac37564a3fa4575ccab642efc7,

title = "Nonlinear conductance-volume relationship for murine conductance catheter measurement system",

abstract = "The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.",

keywords = "Conductance catheter, Conductance-volume relationship, Volume estimation",

author = "Wei, {Chia Ling} and Valvano, {Jonathan W.} and Feldman, {Marc D.} and Pearce, {John A.}",

note = "Funding Information: Manuscript received September 26, 2004; revised March 6, 2005. This work was supported in part by the American Heart Association Texas Affiliate under Grant 0255812Y, in part by the National Institutes of Health under Grant HL-67475, and in part by Millar Instruments, Inc., Houston, Texas. Asterisk indicates corresponding author. *C.-L. Wei was with the Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712 USA. She is now with Silicon Laboratories Inc., 4635 Boston Lane, Austin, TX 78735 USA (e-mail: chia-ling.wei@silabs.com).",

year = "2005",

month = oct,

doi = "10.1109/TBME.2005.856029",

language = "English (US)",

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AU - Wei, Chia Ling

AU - Valvano, Jonathan W.

AU - Feldman, Marc D.

AU - Pearce, John A.

N1 - Funding Information: Manuscript received September 26, 2004; revised March 6, 2005. This work was supported in part by the American Heart Association Texas Affiliate under Grant 0255812Y, in part by the National Institutes of Health under Grant HL-67475, and in part by Millar Instruments, Inc., Houston, Texas. Asterisk indicates corresponding author. *C.-L. Wei was with the Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712 USA. She is now with Silicon Laboratories Inc., 4635 Boston Lane, Austin, TX 78735 USA (e-mail: chia-ling.wei@silabs.com).

PY - 2005/10

Y1 - 2005/10

N2 - The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.

AB - The conductance catheter system is a tool to determine instantaneous left ventricular volume in vivo by converting measured conductance to volume. The currently adopted conductance-to-volume conversion equation was proposed by Baan, and the accuracy of this equation is limited by the assumption of a linear conductance-volume relationship. The electric field generated by a conductance catheter is nonuniform, which results in a nonlinear relationship between conductance and volume. This paper investigates this nonlinear relationship and proposes a new nonlinear conductance-to-volume conversion equation. The proposed nonlinear equation uses a single empirically determined calibration coefficient, derived from independently measured stroke volume. In vitro experiments and numerical model simulations were performed to verify and validate the proposed equation.

KW - Conductance catheter

KW - Conductance-volume relationship

KW - Volume estimation

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Nonlinear conductance-volume relationship for murine conductance catheter measurement system

Abstract

Keywords

ASJC Scopus subject areas

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