Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections

J. R. Mourant; I. J. Bigio; D. C. Gritz; R. D. Glickman; T. Johnson; T. Shimada; K. StoreyHeld

doi:10.1117/12.176002

Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections

J. R. Mourant, I. J. Bigio, D. C. Gritz, R. D. Glickman, T. Johnson, T. Shimada, K. StoreyHeld

Ophthalmology

Research output: Contribution to journal › Conference article › peer-review

Abstract

The potential of a rapid noninvasive diagnostic system to detect tissue abnormalities on the surface of the eye has been investigated. The optical scatter signal from lesions and normal areas on the conjunctival sclera of the human eye were measured in vivo. It is possible to distinguish nonpigmented pingueculas from other lesions. The ability of the system to detect malignancies could not be tested because none of the measured and biopsied lesions were malignant. Optical scatter and fluorescence spectra of bacterial and fungal suspensions, and corneal irritations were also collected. Both scattering and fluorescence show potential for diagnosing corneal infections.

Original language	English (US)
Pages (from-to)	275-284
Number of pages	10
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2135
DOIs	https://doi.org/10.1117/12.176002
State	Published - May 19 1994
Event	Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 1994 - Los Angeles, United States Duration: Jan 23 1994 → Jan 29 1994

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.176002

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Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections. / Mourant, J. R.; Bigio, I. J.; Gritz, D. C.; Glickman, R. D.; Johnson, T.; Shimada, T.; StoreyHeld, K.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 2135, 19.05.1994, p. 275-284.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "The potential of a rapid noninvasive diagnostic system to detect tissue abnormalities on the surface of the eye has been investigated. The optical scatter signal from lesions and normal areas on the conjunctival sclera of the human eye were measured in vivo. It is possible to distinguish nonpigmented pingueculas from other lesions. The ability of the system to detect malignancies could not be tested because none of the measured and biopsied lesions were malignant. Optical scatter and fluorescence spectra of bacterial and fungal suspensions, and corneal irritations were also collected. Both scattering and fluorescence show potential for diagnosing corneal infections.",

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