TY - JOUR
T1 - Noninvasive cardiac psychophysiology as a tool for translational science with marmosets
AU - Murphy, Ashley M.
AU - Ross, Corinna N.
AU - Bliss-Moreau, Eliza
N1 - Funding Information:
Thank you to Raquel Alonsa and Christa Leach who assisted with data collection, Aubrey Sills and the UTHSCSA lab animal resources crew for their care of the marmosets, and Hailey Caparella-Veal who processed the ECG data. EBM was supported by National Institute of Mental Health, grant K99MH10138 during data collection, and the marmoset colony is supported by the Barshop Institute for Longevity and Aging Studies, via National Institute of Health, grants P30AG044271 and R24OD010933.
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The importance of marmosets for comparative and translational science has grown in recent years because of their relatively rapid development, birth cohorts of twins, family social structure, and genetic tractability. Despite this, they remain understudied in investigations of affective processes. In this methodological note, we establish the validity of using noninvasive commercially available equipment to record cardiac physiology and compute indices of autonomic nervous system activity—a major component of affective processes. Specifically, we recorded electrocardiogram and impedance cardiogram, from which we derived heart rate, respiration rate, measures of high-frequency heart rate variability (indices of parasympathetic autonomic nervous system activity), and ventricular contractility (an index of sympathetic autonomic nervous system activity). Our methods produced physiologically plausible data, and further, animals with increased heart rates during testing were also more reactive to isolation from their social partner and presentation of novel objects, though no relationship was observed between reactivity and specific indices of parasympathetic or sympathetic nervous system activity.
AB - The importance of marmosets for comparative and translational science has grown in recent years because of their relatively rapid development, birth cohorts of twins, family social structure, and genetic tractability. Despite this, they remain understudied in investigations of affective processes. In this methodological note, we establish the validity of using noninvasive commercially available equipment to record cardiac physiology and compute indices of autonomic nervous system activity—a major component of affective processes. Specifically, we recorded electrocardiogram and impedance cardiogram, from which we derived heart rate, respiration rate, measures of high-frequency heart rate variability (indices of parasympathetic autonomic nervous system activity), and ventricular contractility (an index of sympathetic autonomic nervous system activity). Our methods produced physiologically plausible data, and further, animals with increased heart rates during testing were also more reactive to isolation from their social partner and presentation of novel objects, though no relationship was observed between reactivity and specific indices of parasympathetic or sympathetic nervous system activity.
KW - affect
KW - autonomic nervous system
KW - heart rate variability
KW - respiratory sinus arrhythmia
KW - ventricular contractility
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U2 - 10.1002/ajp.23037
DO - 10.1002/ajp.23037
M3 - Article
C2 - 31515850
AN - SCOPUS:85073631660
VL - 81
JO - American Journal of Primatology
JF - American Journal of Primatology
SN - 0275-2565
IS - 9
M1 - e23037
ER -