Nonimmune hydrops fetalis: Fetal and neonatal outcome during 1983-1992

Leontien S. Wafelman, Brad H. Pollock, Jacqueline Kreutzer, Douglas S. Richards, Alastair A. Hutchison

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Prognostic factors for survival of 62 fetuses and neonates with nonimmune hydrops fetalis (NIHF) were studied retrospectively. Twenty-eight infants survived ≥ 28 days which is 45% for all fetuses and newborns diagnosed with NIHF and 61% for liveborns with unresolved NIHF. Univariate analysis identified that mortality was associated with the presence of ≥ 2 serous cavity effusions and a need for chest compressions at birth. Multivariate logistic regression analysis confirmed that the presence of ≥ 2 serous cavity effusions was significantly associated with mortality from NIHF < 28 days after birth [OR = 48.2 (CI 3.6, 662.9) (p < 0.004)]. We conclude that, compared to published cases from the 1970s and early 1980s, survival of liveborns with NIHF seems improved. The decrease in stillbirths is more notable. The severity of hydrops at birth is the key determinant for survival.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalBiology of the Neonate
Issue number2
StatePublished - Feb 1999
Externally publishedYes


  • Fetal outcome, hydrops
  • Fetal therapy
  • Multivariate logistic regression analysis
  • Neonatal outcome, hydrops
  • Nonimmune fetal hydrops
  • Prognostic factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology


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