Nonhuman primates and translational research-Cardiovascular disease

Laura A. Cox, Michael Olivier, Kimberly Spradling-Reeves, Genesio M. Karere, Anthony G. Comuzzie, John L. VandeBerg

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Human epidemiological studies provide challenges for understanding mechanisms that regulate initiation and progression of CVD due to variation in lifestyle, diet, and other environmental factors. Studies describing metabolic and physiologic aspects of CVD, and those investigating genetic and epigenetic mechanisms influencing CVD initiation and progression, have been conducted in multiple OldWorld nonhuman primate (NHP) species. Major advantages of NHPs as models for understanding CVD are their genetic, metabolic, and physiologic similarities with humans, and the ability to control diet, environment, and breeding. These NHP species are also genetically and phenotypically heterogeneous, providing opportunities to study gene by environment interactions that are not feasible in inbred animal models. Each OldWorld NHP species included in this review brings unique strengths as models to better understand human CVD. All develop CVD without genetic manipulation providing multiple models to discover genetic variants that influence CVD risk. In addition, as each of these NHP species age, their age-related comorbidities such as dyslipidemia and diabetes are accelerated proportionally 3 to 4 times faster than in humans. In this review, we discuss current CVD-related research in NHPs focusing on selected aspects of CVD for which nonprimate model organism studies have left gaps in our understanding of human disease.We include studies on current knowledge of genetics, epigenetics, calorie restriction, maternal calorie restriction and offspring health, maternal obesity and offspring health, nonalcoholic steatohepatitis and steatosis, Chagas disease, microbiome, stem cells, and prevention of CVD.

    Original languageEnglish (US)
    Pages (from-to)235-250
    Number of pages16
    JournalILAR Journal
    Volume58
    Issue number2
    DOIs
    StatePublished - Dec 1 2017

    Keywords

    • Caloric restriction
    • Chagas disease
    • Epigenetics
    • Genetics
    • Maternal nutrition
    • Non-alcoholic fatty liver disease
    • Stem cells

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • Biochemistry, Genetics and Molecular Biology(all)

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