Nongeometric determination of left ventricular volumes from equilibrium blood pool scans

Gregory J. Dehmer, Samuel E. Lewis, L. David Hillis, Donald Twieg, Michael Falkoff, Robert W. Parkey, James T. Willerson

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


This study assesses the utility of a scintigraphic, nongeometric technique for the determination of left ventricular volumes. Accordingly, gated blood pool scintigraphy and cineangiography were performed within a 24 hour period in 22 patients. Scintigraphic volume measurements were calculated from individual frames of a modified 35 ° left anterior oblique projection using an algorithm designed to consider (1) the background-corrected left ventricular activity normalized for activity per milliliter of peripheral venous blood; (2) total study time; (3) number of frames acquired per cardiac cycle; and (4) percent of the cardiac cycle acquired. Angiographic volumes were calculated by the area-length method and the Kennedy regression equation. There was an excellent correlation between scintigraphic and angiographic methods for all volume measurements grouped together (r = 0.985, standard error of the estimate [SEE] = 14.6 ml) as well as for segregated end-diastolic volumes (r = 0.985, SEE = 16.2 ml) and end-systolic volumes (r = 0.988, SEE = 14.7 ml). Prospective testing of the independent ability of scintigraphy to estimate ventricular volumes was provided for by studying an additional 13 patients, and good agreement was found between scintigraphic and angiographic determinations of left ventricular end-systolic and end-diastolic volumes. Thus, radio nuclide techniques, which are independent of geometric assumptions, may be utilized for the quantitation of left ventricular volumes.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalThe American journal of cardiology
Issue number2
StatePublished - Feb 1980
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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