Non-surgical ablation for breast cancer: an emerging therapeutic option

Masakazu Toi, Takayuki Kinoshita, John R. Benson, Ismail Jatoi, Masako Kataoka, Wonshik Han, Chikako Yamauchi, Takashi Inamoto, Masahiro Takada

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Non-surgical ablation is emerging as an alternative local therapy option for patients with early-stage breast cancer and encompasses two main types of percutaneous therapeutic procedures: radiofrequency ablation and cryoablation. Both techniques involve obliteration of a spherical lesion and feasibility studies have shown that complete tumour ablation is achievable with good or excellent cosmetic results. Although few clinical studies have directly compared non-surgical ablation with conventional surgical resection, observational studies indicate that clinical outcomes are favourable with acceptable rates of local control and no detriment to long-term survival. There remain outstanding issues with these percutaneous ablative techniques that require resolution before they could be incorporated into routine clinical practice. Hence, a consensus meeting was convened to discuss the challenges of non-surgical ablation and clarify indications for its use alongside clinical management pathways. In this Policy Review we will address some of the broader biological aspects of non-surgical ablation, including immune-modulatory effects and potential novel applications for the future.

Original languageEnglish (US)
Pages (from-to)e114-e125
JournalThe Lancet Oncology
Issue number3
StatePublished - Mar 2024

ASJC Scopus subject areas

  • Oncology


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