Non-stroke neurological syndromes associated with antiphospholipid antibodies: Evaluation of clinical and experimental studies

J. Chapman, J. H. Rand, R. L. Brey, S. R. Levine, I. Blatt, M. A. Khamashta, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and rank the association of other neurological manifestations as possible, probable, or definite according to the data available from clinical studies and animal models. By these criteria, none of the neurological disorders or events such as epilepsy, psychiatric disease, dementia, transverse myelitis, multiple sclerosis-like disease, chorea, migraine, Guillian-Barrè syndrome, and sensory-neural hearing loss, can be definitely associated with aPL or APS.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalLupus
Volume12
Issue number7
DOIs
StatePublished - 2003

Keywords

  • Antiphospholipid antibodies
  • Cerebrovascular disease
  • Chorea
  • Dementia
  • Epilepsy
  • Migraine
  • Multiple sclerosis

ASJC Scopus subject areas

  • Rheumatology

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