Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao

Research output: Contribution to journalLetterpeer-review

7 Scopus citations

Abstract

We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

Original languageEnglish (US)
Article number99
JournalJournal of Hematology and Oncology
Volume10
Issue number1
DOIs
StatePublished - May 2 2017
Externally publishedYes

Keywords

  • Myeloproliferative neoplasm-associated myelofibrosis
  • Non-driver mutation
  • Targeted gene sequencing

ASJC Scopus subject areas

  • Hematology
  • Molecular Biology
  • Oncology
  • Cancer Research

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