Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li; Robert Peter Gale; Zefeng Xu; Tiejun Qin; Zhen Song; Peihong Zhang; Jie Bai; Lei Zhang; Yue Zhang; Jinqin Liu; Gang Huang; Zhijian Xiao

doi:10.1186/s13045-017-0472-5

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao

Research output: Contribution to journal › Letter › peer-review

10 Scopus citations

Abstract

We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

Original language	English (US)
Article number	99
Journal	Journal of Hematology and Oncology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13045-017-0472-5
State	Published - May 2 2017
Externally published	Yes

Keywords

Myeloproliferative neoplasm-associated myelofibrosis
Non-driver mutation
Targeted gene sequencing

ASJC Scopus subject areas

Molecular Biology
Hematology
Oncology
Cancer Research

Access to Document

10.1186/s13045-017-0472-5

Cite this

@article{69cd872e682a49a6830adf163a7db181,

title = "Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis",

abstract = "We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.",

keywords = "Myeloproliferative neoplasm-associated myelofibrosis, Non-driver mutation, Targeted gene sequencing",

author = "Bing Li and Gale, {Robert Peter} and Zefeng Xu and Tiejun Qin and Zhen Song and Peihong Zhang and Jie Bai and Lei Zhang and Yue Zhang and Jinqin Liu and Gang Huang and Zhijian Xiao",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = may,

day = "2",

doi = "10.1186/s13045-017-0472-5",

language = "English (US)",

volume = "10",

journal = "Journal of Hematology and Oncology",

issn = "1756-8722",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

AU - Li, Bing

AU - Gale, Robert Peter

AU - Xu, Zefeng

AU - Qin, Tiejun

AU - Song, Zhen

AU - Zhang, Peihong

AU - Bai, Jie

AU - Zhang, Lei

AU - Zhang, Yue

AU - Liu, Jinqin

AU - Huang, Gang

AU - Xiao, Zhijian

PY - 2017/5/2

Y1 - 2017/5/2

N2 - We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

AB - We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

KW - Myeloproliferative neoplasm-associated myelofibrosis

KW - Non-driver mutation

KW - Targeted gene sequencing

UR - http://www.scopus.com/inward/record.url?scp=85018249626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018249626&partnerID=8YFLogxK

U2 - 10.1186/s13045-017-0472-5

DO - 10.1186/s13045-017-0472-5

M3 - Letter

C2 - 28464892

AN - SCOPUS:85018249626

SN - 1756-8722

VL - 10

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

IS - 1

M1 - 99

ER -

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this