Non-coding RNAs in endodontic disease

Johnah Galicia; Asma A. Khan

doi:10.1016/j.semcdb.2021.07.006

Non-coding RNAs in endodontic disease

Johnah Galicia, Asma A. Khan

Department of Endodontics

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The immunocompetence and regeneration potential of the dental pulp and its surrounding apical tissues have been investigated extensively in the field of endodontics. While research on the role of non-coding RNAs in these tissues is still in its infancy, it is envisioned that improved understanding of the regulatory function of ncRNAs in pulpal and periapical immune response will help prevent or treat endodontic disease. Of particular importance is the role of these RNAs in regenerating the dentin-pulp complex. In this review, we highlight recent progress on the role of non-coding RNAs in the immune response to endodontic infection as well as the repair and regenerative response to injury.

Original language	English (US)
Pages (from-to)	82-84
Number of pages	3
Journal	Seminars in Cell and Developmental Biology
Volume	124
DOIs	https://doi.org/10.1016/j.semcdb.2021.07.006
State	Published - Apr 2022

Keywords

Dental
Epigenetic
MicroRNA
Non-coding RNA
SiRNAs

ASJC Scopus subject areas

Cell Biology
Developmental Biology

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10.1016/j.semcdb.2021.07.006

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title = "Non-coding RNAs in endodontic disease",

abstract = "The immunocompetence and regeneration potential of the dental pulp and its surrounding apical tissues have been investigated extensively in the field of endodontics. While research on the role of non-coding RNAs in these tissues is still in its infancy, it is envisioned that improved understanding of the regulatory function of ncRNAs in pulpal and periapical immune response will help prevent or treat endodontic disease. Of particular importance is the role of these RNAs in regenerating the dentin-pulp complex. In this review, we highlight recent progress on the role of non-coding RNAs in the immune response to endodontic infection as well as the repair and regenerative response to injury.",

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AB - The immunocompetence and regeneration potential of the dental pulp and its surrounding apical tissues have been investigated extensively in the field of endodontics. While research on the role of non-coding RNAs in these tissues is still in its infancy, it is envisioned that improved understanding of the regulatory function of ncRNAs in pulpal and periapical immune response will help prevent or treat endodontic disease. Of particular importance is the role of these RNAs in regenerating the dentin-pulp complex. In this review, we highlight recent progress on the role of non-coding RNAs in the immune response to endodontic infection as well as the repair and regenerative response to injury.

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KW - Epigenetic

KW - MicroRNA

KW - Non-coding RNA

KW - SiRNAs

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Non-coding RNAs in endodontic disease

Abstract

Keywords

ASJC Scopus subject areas

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