Non-bulk-like water on cellular interfaces

Ivan L. Cameron, Gary D. Fullerton

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Given that a major fraction of cellular water is non-bulk-like in its physical properties the question arises: What is the molecular basis of this non-bulk water? As proteins are, by mass, the major solute in the cell it is natural to suspect proteins as the main factor responsible for the non-bulk properties of water in cells. This report reviews possible theories and facts on the origins of this non-bulk-like cellular water. After review of theories in the literature it is concluded that native globular proteins in their free and polymerized state can account for the major fraction of cell water as being non-bulk-like in its physical properties

Original languageEnglish (US)
Title of host publicationWater and the Cell
PublisherSpringer Netherlands
Number of pages10
ISBN (Print)1402049269, 9781402049262
StatePublished - 2006


  • Cell water
  • Hydration
  • Hydrophilic
  • Hydrophobic
  • Interfaces
  • Intracellular water
  • Osmosis
  • Protein conformation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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