Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

Melania Gaggini, Mariangela Morelli, Emma Buzzigoli, Ralph A. DeFronzo, Elisabetta Bugianesi, Amalia Gastaldelli

Research output: Contribution to journalReview articlepeer-review

367 Scopus citations

Abstract

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1544-1560
Number of pages17
JournalNutrients
Volume5
Issue number5
DOIs
StatePublished - May 10 2013

Keywords

  • Cardiometabolic risk
  • Dyslipidemia
  • Free fatty acids
  • Insulin resistance
  • Lipotoxicity
  • Non-alcoholic fatty liver (NAFLD)
  • Steatosis
  • Visceral fat

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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