Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

Melania Gaggini; Mariangela Morelli; Emma Buzzigoli; Ralph A. DeFronzo; Elisabetta Bugianesi; Amalia Gastaldelli

doi:10.3390/nu5051544

Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

Melania Gaggini, Mariangela Morelli, Emma Buzzigoli, Ralph A. DeFronzo, Elisabetta Bugianesi, Amalia Gastaldelli

Research output: Contribution to journal › Review article › peer-review

688 Scopus citations

Abstract

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.

Original language	English (US)
Pages (from-to)	1544-1560
Number of pages	17
Journal	Nutrients
Volume	5
Issue number	5
DOIs	https://doi.org/10.3390/nu5051544
State	Published - May 10 2013

Keywords

Cardiometabolic risk
Dyslipidemia
Free fatty acids
Insulin resistance
Lipotoxicity
Non-alcoholic fatty liver (NAFLD)
Steatosis
Visceral fat

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu5051544

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abstract = "Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.",

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AU - Gaggini, Melania

AU - Morelli, Mariangela

AU - Buzzigoli, Emma

AU - DeFronzo, Ralph A.

AU - Bugianesi, Elisabetta

AU - Gastaldelli, Amalia

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AB - Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.

KW - Cardiometabolic risk

KW - Dyslipidemia

KW - Free fatty acids

KW - Insulin resistance

KW - Lipotoxicity

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KW - Steatosis

KW - Visceral fat

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Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

Abstract

Keywords

ASJC Scopus subject areas

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