Nomofungin: A new microfilament disrupting agent

A. S. Ratnayake, W. Y. Yoshida, S. L. Mooberry, T. K. Hemscheidt

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A new alkaloid, nomofungin, has been isolated from the fermentation broth of an unidentified endophytic fungus obtained from the bark of Ficus microcarpa L. The structure of nomofungin was determined by application of spectroscopic methods. The absolute stereochemistry of nomofungin was assigned by using the exciton chirality method. Nomofungin disrupts microfilaments in cultured mammalian cells and is moderately cytotoxic with minimum inhibitory concentrations (MICs) of 2 and 4.5 μg/mL against LoVo and KB cells, respectively. The ring system of nomofungin is unprecedented.

Original languageEnglish (US)
Pages (from-to)8717-8721
Number of pages5
JournalJournal of Organic Chemistry
Volume66
Issue number26
DOIs
StatePublished - Dec 28 2001
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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